Syntaxin-binding protein

Function

Syntaxin-binding proteins (STXBP) are involved in the regulation of synaptic vesicle docking and fusion. STXBP1 participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding Syntaxin-1 and as a fusion protein that binds SNARE complexes in a Syntaxin-1 N-peptide-dependent manner^[1]. STXBP2 binds SNARE proteins.

Structural highlights

which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds. The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions^[1].