Polycomb proteins

From Proteopedia

(Redirected from Polycomb)

Human polycomb complex protein BMI-1 (olive and dark red) complex with histones (grey, green, yellow, pink, magenta, cyan, gold, red), RING1B/Ubch5C (aqua and orchid)and DNA (blue and gold) PDB code 4r8p

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3D structures of polycomb proteins

Polycomb complex proteins 3D structures

References

↑ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C. A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096. PMID:27705803 doi:http://dx.doi.org/10.1016/j.celrep.2016.08.096
↑ Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Hutchins AP, Sun H, Wang H, Yao H. PCGF5 is required for neural differentiation of embryonic stem cells. Nat Commun. 2018 May 15;9(1):1463. doi: 10.1038/s41467-018-03781-0. PMID:29765032 doi:http://dx.doi.org/10.1038/s41467-018-03781-0
↑ Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol. 2007 May;27(10):3769-79. PMID:17339329 doi:10.1128/MCB.01432-06
↑ Liu M, Zhu Y, Xing F, Liu S, Xia Y, Jiang Q, Qin J. The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters. J Biol Chem. 2020 Jul 10;295(28):9712-9724. doi: 10.1074/jbc.RA119.012121. Epub , 2020 Jun 1. PMID:32482889 doi:http://dx.doi.org/10.1074/jbc.RA119.012121
↑ Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, Poliakov A, Yocum AK, Li Y, Chen W, Cao X, Jiang X, Dahiya A, Harris C, Feng FY, Kalantry S, Qin ZS, Dhanasekaran SM, Chinnaiyan AM. The central role of EED in the orchestration of polycomb group complexes. Nat Commun. 2014;5:3127. PMID:24457600 doi:10.1038/ncomms4127
↑ Takada Y, Isono K, Shinga J, Turner JM, Kitamura H, Ohara O, Watanabe G, Singh PB, Kamijo T, Jenuwein T, Burgoyne PS, Koseki H. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development. 2007 Feb;134(3):579-90. PMID:17215307 doi:10.1242/dev.02747
↑ Feijão T, Marques B, Silva RD, Carvalho C, Sobral D, Matos R, Tan T, Pereira A, Morais-de-Sá E, Maiato H, DeLuca SZ, Martinho RG. Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis. Proc Natl Acad Sci U S A. 2022 Oct 18;119(42):e2204701119. PMID:36215502 doi:10.1073/pnas.2204701119
↑ Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, Kyba M, Randazzo F, Brock HW. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Development. 1998 Apr;125(7):1207-16. PMID:9477319
↑ Poynter ST, Kadoch C. Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol. 2016 Nov;5(6):659-688. doi: 10.1002/wdev.244., Epub 2016 Sep 1. PMID:27581385 doi:http://dx.doi.org/10.1002/wdev.244