Structural highlights
Function
QEDH_PSEAE Catalyzes the oxidation of ethanol and other primary alcohols to the corresponding aldehydes, except methanol, which is a very poor substrate. Uses a specific inducible cytochrome c550, encoded by the adjacent gene in the locus, as electron acceptor. Is a key enzyme of the carbon and energy metabolism during growth of P.aeruginosa on ethanol as the sole carbon and energy source. Is also able to use secondary alcohols as well as aminoalcohols like ethanolamine and 1-amino-2-propanol, and aldehydes as substrates.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Mennenga B, Kay CW, Görisch H. Quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: the unusual disulfide ring formed by adjacent cysteine residues is essential for efficient electron transfer to cytochrome c550. Arch Microbiol. 2009 Apr;191(4):361-7. PMID:19224199 doi:10.1007/s00203-009-0460-4
- ↑ Rupp M, Görisch H. Purification, crystallisation and characterization of quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa. Biol Chem Hoppe Seyler. 1988 Jun;369(6):431-9. PMID:3144289 doi:10.1515/bchm3.1988.369.1.431
- ↑ Reichmann P, Görisch H. Cytochrome c550 from Pseudomonas aeruginosa. Biochem J. 1993 Jan 1;289 ( Pt 1)(Pt 1):173-8. PMID:8380982 doi:10.1042/bj2890173
