5ltv

Structural highlights

Function

PCTC_PSEAE Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His, L-Pro and gamma-aminobutyrate (GABA). Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate (PubMed:16233808, PubMed:23650915, PubMed:9353923). Also mediates chemotaxis to histamine, but does not bind histamine (PubMed:30425146).^{[1] [2] [3] [4]}

See Also

• Chemotaxis protein 3D structures

References

1. ↑ Shitashiro M, Tanaka H, Hong CS, Kuroda A, Takiguchi N, Ohtake H, Kato J. Identification of chemosensory proteins for trichloroethylene in Pseudomonas aeruginosa. J Biosci Bioeng. 2005 Apr;99(4):396-402. PMID:16233808 doi:http://dx.doi.org/10.1263/jbb.99.396
2. ↑ Rico-Jimenez M, Munoz-Martinez F, Garcia-Fontana C, Fernandez M, Morel B, Ortega A, Ramos JL, Krell T. Paralogous chemoreceptors mediate chemotaxis towards protein amino acids and the non-protein amino acid gamma-aminobutyrate (GABA). Mol Microbiol. 2013 Jun;88(6):1230-43. doi: 10.1111/mmi.12255. Epub 2013 May 22. PMID:23650915 doi:http://dx.doi.org/10.1111/mmi.12255
3. ↑ Corral-Lugo A, Matilla MA, Martin-Mora D, Silva Jimenez H, Mesa Torres N, Kato J, Hida A, Oku S, Conejero-Muriel M, Gavira JA, Krell T. High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa. MBio. 2018 Nov 13;9(6). pii: mBio.01894-18. doi: 10.1128/mBio.01894-18. PMID:30425146 doi:http://dx.doi.org/10.1128/mBio.01894-18
4. ↑ Taguchi K, Fukutomi H, Kuroda A, Kato J, Ohtake H. Genetic identification of chemotactic transducers for amino acids in Pseudomonas aeruginosa. Microbiology. 1997 Oct;143 ( Pt 10):3223-9. PMID:9353923 doi:http://dx.doi.org/10.1099/00221287-143-10-3223