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6s8d is a 12 chain structure with sequence from Ebov and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The VH3-15/Vlambda1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three VH3-15/Vlambda1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the VH3-15/Vlambda1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of VH3-15/Vlambda1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.
Structural Basis for a Convergent Immune Response against Ebola Virus.,Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R Cell Host Microbe. 2020 Feb 6. pii: S1931-3128(20)30046-9. doi:, 10.1016/j.chom.2020.01.007. PMID:32059794[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R. Structural Basis for a Convergent Immune Response against Ebola Virus. Cell Host Microbe. 2020 Feb 6. pii: S1931-3128(20)30046-9. doi:, 10.1016/j.chom.2020.01.007. PMID:32059794 doi:http://dx.doi.org/10.1016/j.chom.2020.01.007
