Structural highlights
Publication Abstract from PubMed
High throughput screening for beta-lactamase inhibitors afforded biphenyl hits such as 1. Hit confirmation and X-ray soaking experiments with Pseudomonas Aeruginosa AmpC enzyme led to the identification of an aryl boronic acid-serine complex 4, which was formed from phenyl boronic acid 8 (an impurity in compound 1) and ethylene glycol (the cryoprotectant in the soaking experiment).
Serendipitous discovery of aryl boronic acids as beta-lactamase inhibitors.,Yang SW, Pan J, Root Y, Scapin G, Xiao L, Su J Bioorg Med Chem Lett. 2019 Nov 9:126795. doi: 10.1016/j.bmcl.2019.126795. PMID:31759850[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Yang SW, Pan J, Root Y, Scapin G, Xiao L, Su J. Serendipitous discovery of aryl boronic acids as beta-lactamase inhibitors. Bioorg Med Chem Lett. 2019 Nov 9:126795. doi: 10.1016/j.bmcl.2019.126795. PMID:31759850 doi:http://dx.doi.org/10.1016/j.bmcl.2019.126795
