7xvk

Structural highlights

Function

2AAB_ARATH The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Involved during developmental process such as seedling and floral developments. Seems to act as a negative regulator of PP2A catalytic activity. Associates with the serine/threonine-protein phosphatase PP2A catalytic subunit C and regulatory subunit B' to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosphorylating peroxisomal beta-oxidation-related proteins (PubMed:25489022).^{[1] [2]}

References

1. ↑ Zhou HW, Nussbaumer C, Chao Y, DeLong A. Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Plant Cell. 2004 Mar;16(3):709-22. PMID:14973165 doi:10.1105/tpc.018994
2. ↑ Kataya AR, Heidari B, Hagen L, Kommedal R, Slupphaug G, Lillo C. Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation. Plant Physiol. 2015 Feb;167(2):493-506. PMID:25489022 doi:10.1104/pp.114.254409