9bxp

Structural highlights

Function

FTNA_PSEAE Plays a role in catalase A (katA) expression; activity is required for optimal KatA activity and resistance to H(2)O(2) (PubMed:10368148). Iron-storage protein that is part of the heterooligomeric bacterioferritin (BFR) complex (PubMed:35327558, PubMed:7998985). The ferroxidase center binds Fe(2+), oxidizes it using dioxygen to Fe(3+), and participates in subsequent Fe(3+) oxide mineral core formation within the central cavity of the BFR protein shell (PubMed:21574546). Can store up to 520 iron atoms per ferritin protein molecule (PubMed:21574546). Iron release requires only the input of electrons from ferredoxin NADP reductase (FPR), does not require Bfd (PubMed:21574546). Does not bind heme (PubMed:21574546).^{[1] [2] [3] [4] [5]}

References

1. ↑ Ma JF, Ochsner UA, Klotz MG, Nanayakkara VK, Howell ML, Johnson Z, Posey JE, Vasil ML, Monaco JJ, Hassett DJ. Bacterioferritin A modulates catalase A (KatA) activity and resistance to hydrogen peroxide in Pseudomonas aeruginosa. J Bacteriol. 1999 Jun;181(12):3730-42. PMID:10368148 doi:10.1128/JB.181.12.3730-3742.1999
2. ↑ Yao H, Jepkorir G, Lovell S, Nama PV, Weeratunga S, Battaile KP, Rivera M. Two Distinct Ferritin-like Molecules in Pseudomonas aeruginosa: The Product of the bfrA Gene Is a Bacterial Ferritin (FtnA) and Not a Bacterioferritin (Bfr). Biochemistry. 2011 May 20. PMID:21574546 doi:10.1021/bi2004119
3. ↑ Yao H, Soldano A, Fontenot L, Donnarumma F, Lovell S, Chandler JR, Rivera M. Pseudomonas aeruginosa Bacterioferritin Is Assembled from FtnA and BfrB Subunits with the Relative Proportions Dependent on the Environmental Oxygen Availability. Biomolecules. 2022 Feb 25;12(3):366. PMID:35327558 doi:10.3390/biom12030366
4. ↑ Moore GR, Kadir FH, al-Massad FK, Le Brun NE, Thomson AJ, Greenwood C, Keen JN, Findlay JB. Structural heterogeneity of Pseudomonas aeruginosa bacterioferritin. Biochem J. 1994 Dec 1;304 ( Pt 2)(Pt 2):493-7. PMID:7998985 doi:10.1042/bj3040493
5. ↑ Yao H, Jepkorir G, Lovell S, Nama PV, Weeratunga S, Battaile KP, Rivera M. Two Distinct Ferritin-like Molecules in Pseudomonas aeruginosa: The Product of the bfrA Gene Is a Bacterial Ferritin (FtnA) and Not a Bacterioferritin (Bfr). Biochemistry. 2011 May 20. PMID:21574546 doi:10.1021/bi2004119