Function
Deaminase removes an amine group from an amino acid and the rest of the molecule is recycled.
- Cytosine deaminase (CDA) converts cytosine to uracil.
- Cytidine deaminase (CDDA) converts cytidine to uridine. [1]
- 5-methylcytosine deaminase (MCDA) produces thymine.
- Guanine deaminase (GDA) converts guanine to xanthine. [2]
- Adenine deaminase (ADA) converts adenine to hypoxanthine.
- Glucosamine 6-phosphate deaminase (GPD) converts glucosamine 6-phosphate to fructose 6-phosphate.
- 1-aminocyclopropane-1-carboxylate deaminase (ACCD) converts 1-aminocyclopropane-1-carboxylic acid to 2-oxobutyrate.
- dCTP deaminase (ADA) converts dCTP to dUTP.
- dCTP deaminase-dUTPase (DCD-DUT) converts dCTP to dUMP.
- Blasticidin-S deaminase (BSD) converts blasticidin-S to deaminohydroxyblasticidin.
- Threonine deaminase (THD) converts L-threonine to α-ketobutyrate.
- L-serine deaminase (LSD) converts L-serine to pyruvate.
- D-serine deaminase (DSD) converts D-serine to pyruvate.
- Aminofutalosine deaminase deaminates aminofutalosine which is an intermediate in the menaquinone biosynthesis in Helicobacter pylori [3].
Relevance
Cytosine deaminase is used in cancer therapy. After treatment by 5-fluorouracil, the cytosine deaminase gene is introduced to the tumor resulting in intratumor chemotherapy. [4]
Disease
Mutation in adenine deaminase results in deficiency of the enzyme and is the cause of severe combined immunodeficiency (SCID).
Structural highlights
The atom.[5]
3D Structures of deaminase
Deaminase 3D structures
