Insulin-like growth factor

From Proteopedia

spinqualitylabelsall models Structure of insulin-like growth factor I complex with detergent (PDB entry 1gzr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Insulin-like growth factor (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme[1]. IGF I is secreted in the liver after stimulation by growth hormone. See details in IGF1 and Igf1 - alec. IGF II is required in early development stages. Relevance Inhibition of IGF I influences colon cancer[2]. IGF I has protective effect in neuropathy[3]. See also Insulin-like growth factor receptor and Insulin-like growth factor 1.

3D structures of insulin-like growth factor

Updated on 17-January-2024

References

1. ↑ Wood AW, Duan C, Bern HA. Insulin-like growth factor signaling in fish. Int Rev Cytol. 2005;243:215-85. PMID:15797461 doi:http://dx.doi.org/10.1016/S0074-7696(05)43004-1
2. ↑ Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S. PMID:11694656
3. ↑ Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol. 2002;1(6):399-410. PMID:15832492