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- Image:Inactive mGlu.png (0 bytes)
- Image:Overview mGlu.jpg (0 bytes)
- Image:Overview mGlu 2.jpg (0 bytes)
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- 7e9g (4,405 bytes)
2: ...cture of Gi-bound metabotropic glutamate receptor mGlu2==
14: ...r basis for the asymmetric signal transduction of mGlus. These findings offer insights into receptor sig...
16: ...-bound metabotropic glutamate receptors mGlu2 and mGlu4.,Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wan... - 7e9h (4,006 bytes)
2: ...cture of Gi-bound metabotropic glutamate receptor mGlu4==
14: ...r basis for the asymmetric signal transduction of mGlus. These findings offer insights into receptor sig...
16: ...-bound metabotropic glutamate receptors mGlu2 and mGlu4.,Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wan... - Metabotropic glutamate receptor 5 (21,092 bytes)
9: ...des in the cellular membrane <ref name="Dore" />. mGlu5 is a member of the Class C GPCR family and can f...
10: ...nformational changes throughout multiple domains. mGlu5 will bind glutamate through its extracellular Ve...
12: ...he CNS and the presence of multiple domains makes mGlu5 an excellent target for treating neurological co...
14: ...ft|thumb|'''Figure 1''': Overall Structure of the mGlu5 TMD. The polar heads on the Oleic acids orient t...
16: .../>. The hydrophobic nature and flexibility of the mGlu5 TMD made it difficult to crystallize. - 3if5 (2,370 bytes)
2: ==Crystal Structure Analysis of Mglu== - 3ih8 (4,256 bytes)
2: ==Crystal Structure Analysis of Mglu in its native form==
23: ...has substrates other than L-glutamine, shows that Mglu has a larger substrate-binding pocket that preven... - 3ih9 (4,254 bytes)
2: ==Crystal Structure Analysis of Mglu in its tris form==
23: ...has substrates other than L-glutamine, shows that Mglu has a larger substrate-binding pocket that preven... - 3iha (4,429 bytes)
2: ==Crystal Structure Analysis of Mglu in its glutamate form==
24: ...has substrates other than L-glutamine, shows that Mglu has a larger substrate-binding pocket that preven... - 3ihb (4,520 bytes)
2: ==Crystal Structure Analysis of Mglu in its tris and glutamate form==
24: ...has substrates other than L-glutamine, shows that Mglu has a larger substrate-binding pocket that preven... - 3agd (1,566 bytes)
2: ==Crystal structure of Mglu in its native form in the presence of 4.3M NaCl== - 3age (1,749 bytes)
2: ==Crystal structure of Mglu in its L-glutamate binding form in the presence o... - Image:Flytrap.spt (106 bytes)
2: Venus Flytrap-like action of N-terminal domain of mGlu receptors - Image:MgluSM.png (16 bytes)
1: mglu family tree - 8jcx (5,199 bytes)
2: ==Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (...
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jcy (5,265 bytes)
2: ==Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and...
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jcz (5,212 bytes)
2: ==Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and...
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jd0 (5,312 bytes)
2: ==Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563==
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jd1 (5,096 bytes)
2: ==Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state==
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jd2 (5,122 bytes)
2: ==Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state==
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jd3 (4,472 bytes)
2: ==Cryo-EM structure of Gi1-bound mGlu2-mGlu3 heterodimer==
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao... - 8jd4 (5,090 bytes)
2: ==Cryo-EM structure of G protein-free mGlu2-mGlu4 heterodimer in Acc state==
14: ...nd our knowledge about signal transduction of the mGlus.
16: ...ation and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.,Wang X, Wang M, Xu T, Feng Y, Shao...
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