This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

Moesin

From Proteopedia

Jump to: navigation, search

Mouse moesin FERM domain (green) complex with Crumbs C-terminal peptide (magenta), glycerol and I- ions (purple) (PDB code 4yl8).

Drag the structure with the mouse to rotate

3D structures of moesin

Updated on 02-July-2023

3u8z - hMO FERM domain 1-296 - human
8cit, 8ciu - hMO FERM domain (mutant)
1ef1 - hMO FERM domain + C-terminal domain 487-576
1e5w - hMO FERM domain + 1st helix 297-345
6txq - hMO FERM+helical linker domains - Cryo EM
6txs - hMO FERM+helical linker domains + CD44 peptide
1sgh - hMO FERM domain + EBP50 peptide
8cir, 8cis - hMO FERM domain + peptide
4yl8 - MO FERM domain + Crumbs C-terminal peptide - mouse
2i1k, 2i1j - MO - armyworm

References

↑ Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Salem M, Riesenberg B, Sun S, Rockey DC, Karvar S, Howe PH, Liu B, Li Z. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-beta signaling. J Clin Invest. 2017 Apr 3;127(4):1321-1337. doi: 10.1172/JCI89281. Epub 2017 Mar , 13. PMID:28287407 doi:http://dx.doi.org/10.1172/JCI89281
↑ Freymuth PS, Fitzsimons HL. The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila. Mol Brain. 2017 Aug 29;10(1):41. doi: 10.1186/s13041-017-0322-y. PMID:28851405 doi:http://dx.doi.org/10.1186/s13041-017-0322-y
↑ Karvar S, Ansa-Addo EA, Suda J, Singh S, Zhu L, Li Z, Rockey DC. Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis. Hepatology. 2019 Dec 20. doi: 10.1002/hep.31078. PMID:31860744 doi:http://dx.doi.org/10.1002/hep.31078
↑ Wei Z, Li Y, Ye F, Zhang M. Structural basis for the phosphorylation-regulated interaction between the cytoplasmic tail of cell polarity protein Crumbs and the actin binding protein Moesin. J Biol Chem. 2015 Mar 19. pii: jbc.M115.643791. PMID:25792740 doi:http://dx.doi.org/10.1074/jbc.M115.643791