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OmpF

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PDB ID 3o0e

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OmpF complex with colicin peptide and beta-octylglucoside, 3o0e
Ligands:


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml




OmpF is a major outer membrane porin found in E. coli. Mutations in the ompF gene result in a reduced sensitivity of the E. coli cell to proteins such as Colicins, and also bacteriophages[1].

OmpF production is regulated by OmpR, a protein that is phosphorylated by EnvZ to induce DNA binding to the promotor region of OmpF, and repress transcription of OmpF[2][3].

This structure shows a monomer of , bound to a of a region of the translocation domain of Colicin E9.

3D structures of porin

Porin

References

  1. ↑ Lavina M, Pugsley AP, Moreno F. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12. J Gen Microbiol. 1986 Jun;132(6):1685-93. PMID:3543211
  2. ↑ Forst S, Delgado J, Inouye M. Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in Escherichia coli. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6052-6. PMID:2668953
  3. ↑ Forst SA, Delgado J, Inouye M. DNA-binding properties of the transcription activator (OmpR) for the upstream sequences of ompF in Escherichia coli are altered by envZ mutations and medium osmolarity. J Bacteriol. 1989 Jun;171(6):2949-55. PMID:2656631

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