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Article title matches
- Image:PONATINIB.jpg (22 bytes)
1: Ponatinib bound to Abl - Category:Ponatinib (40 bytes)
1: List of pages with the keyword Ponatinib
Page text matches
- 3zos (4,059 bytes)
2: ...ructure of the DDR1 kinase domain in complex with ponatinib==
14: ...ated outside the ATP pocket. Whereas imatinib and ponatinib bind potently to both the DDR and ABL kinases, th... - 9p6a (1,995 bytes)
2: ==The catalytic domain of MEKK2 in complex with ponatinib== - SandboxPKA (24,333 bytes)
9: [[Image:figura1jc.jpg|thumb|left|'''c-Abl/Bcr-Abl diagram:''' (a): c-Ab...
72: [[Image:Almu_reaction.jpg|thumb|right]]
138: ==== Ponatinib (AP24534)====
140: [[Image:PONATINIB.jpg|thumb|left|Ponatinib bound to Abl]]
142: Ponatinib was identified using structure base drug design a... - Bcr-Abl and Imatinib (STI571 or Gleevec) (24,297 bytes)
8: [[Image:figura1jd.jpg|thumb|400px|left|'''c-Abl/Bcr-Abl diagram:''' (a)...
69: [[Image:Almu_reaction.jpg|thumb|400px|left]]
137: ==== Ponatinib (AP24534)====
139: [[Image:PONATINIB.jpg|thumb|400px|left|Ponatinib bound to Abl]]
141: Ponatinib was identified using structure base drug design a... - 8s17 (5,002 bytes)
2: ==c-KIT kinase domain in complex with ponatinib== - 3oxz (6,270 bytes)
14: ...utations. The inhibitory mechanism exemplified by ponatinib may have broad relevance to designing inhibitors ...
16: Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibito... - 3oy3 (6,337 bytes)
14: ...utations. The inhibitory mechanism exemplified by ponatinib may have broad relevance to designing inhibitors ...
16: Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibito... - Sandbox423 (4,126 bytes)
16: ...onnor Walsh -- fibroblast growth factor receptor/ Ponatinib (cancer)(4uxq) - Student Projects for UMass Chemistry 423 Spring 2016 (14,869 bytes)
139: ...onnor Walsh -- fibroblast growth factor receptor/ Ponatinib (cancer)(4uxq) - Sandbox Reserved 425 (9,939 bytes)
5: =='''Fibroblast Growth Factor Receptor/Ponatinib (4uxq) <ref name="one">PMID: 25465127</ref>'''==
9: ... load='4uxq' size='350' side='right' caption='The Ponatinib-FGFR complex is highly effective for treating CML...
15: ...-ABL flipped out of its hydrophobic binding site. Ponatinib is the first of its kind to be able to inhibit th...
17: Ponatinib's harmful side effects have caused it to fall und...
21: ...secondary structure</scene>, FGFR in complex with Ponatinib consists of two domains, which is the characteris... - Image:PONATINIB.jpg (22 bytes)
1: Ponatinib bound to Abl - 9gzh (6,172 bytes)
2: ==PDGFRA-T674I in complex with covalent ponatinib derivative 19== - 4bkj (4,048 bytes)
14: ...ated outside the ATP pocket. Whereas imatinib and ponatinib bind potently to both the DDR and ABL kinases, th... - 8fo7 (5,196 bytes)
16: ...LRRK2-IN-1 and GNE-7915) and type II (rebastinib, ponatinib, and GZD-824) inhibitors, uncovering the structur... - 4c8b (4,866 bytes)
2: ... the kinase domain of human RIPK2 in complex with ponatinib==
14: ...ned the first crystal structure of RIPK2 bound to ponatinib, and identified an allosteric site for inhibitor ... - 4qq5 (5,224 bytes)
14: ...gh combining the salient inhibitory mechanisms of ponatinib and FIIN-2. - 4qqj (4,969 bytes)
14: ...gh combining the salient inhibitory mechanisms of ponatinib and FIIN-2. - 4qqt (4,937 bytes)
14: ...gh combining the salient inhibitory mechanisms of ponatinib and FIIN-2. - 4qrc (5,127 bytes)
2: ...e Kinase Domain of FGF Receptor 4 in Complex with Ponatinib==
14: ...gh combining the salient inhibitory mechanisms of ponatinib and FIIN-2. - 4twp (8,128 bytes)
16: ...resistance to all approved ABL1 inhibitors except ponatinib, which has toxicity limitations. Here we combine ...
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