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Monomers Per Turn

The ARC-1 model has 6.4 monomer chains per turn (56.0 degrees rotation between monomers). This is more chains/turn than some previous type IV pilus models.

To visualize chains/turn, we show (alpha carbon of Phe51). Then these chain-marking-atoms are , and the resulting helix is viewed from one end. When counting the chains/turn, bear in mind that the first and last (to complete one turn) count as 1/2 chain each.

Pilus

Chains/Turn (Angle)

Image

Geobacter sulfurreducens (type IVa, 61 amino acids, theoretical model, 2016)[1]

6.4 (56.0°)

Pseudomonas aeruginosa (type IVa, 150 amino acids, fiber diffraction, 2004)[2]

4.0 (90°)

Vibrio cholerae (type IVb, 198 amino acids, cryo-EM, 2012)[3]

3.7 (96.8°)

Neisseria gonorrhoeae (type IVa, 165 amino acids, cryo-EM, 2006)[4]

3.6 (100.8°)


Notes & References

  1. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named xiao1
  2. ↑ Craig L, Pique ME, Tainer JA. Type IV pilus structure and bacterial pathogenicity. Nat Rev Microbiol. 2004 May;2(5):363-78. PMID:15100690 doi:http://dx.doi.org/10.1038/nrmicro885
  3. ↑ Li J, Egelman EH, Craig L. Structure of the Vibrio cholerae Type IVb Pilus and stability comparison with the Neisseria gonorrhoeae type IVa pilus. J Mol Biol. 2012 Apr 20;418(1-2):47-64. doi: 10.1016/j.jmb.2012.02.017. Epub 2012, Feb 21. PMID:22361030 doi:http://dx.doi.org/10.1016/j.jmb.2012.02.017
  4. ↑ Craig L, Volkmann N, Arvai AS, Pique ME, Yeager M, Egelman EH, Tainer JA. Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions. Mol Cell. 2006 Sep 1;23(5):651-62. PMID:16949362 doi:10.1016/j.molcel.2006.07.004
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