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<span style="font-size:150%"><font color="red">Please do not edit this page. Eric Martz, February 2011.</font></span> <Structure size='450' frame='true' align='right' scene='Sandbox6_Eric_Martz/83-341/1' /> *Homology model of 83-341 on template chain A of [[3e4c]], 52% sequence identity (<scene name='Sandbox6_Eric_Martz/83-341/1'>restore initial scene</scene>). {{Template:ColorKey_Amino2CarboxyRainbow}} *<scene name='Sandbox6_Eric_Martz/83-341/2'>Segment 83-140</scene>. *The <scene name='Sandbox6_Eric_Martz/83-341_charge/1'>distribution of charges</scene> seems unremarkable. Bear in mind that sidechain positions are incorrect in a homology model. {{Template:ColorKey_Charge_Anionic}} / {{Template:ColorKey_Charge_Cationic}} *The inner face of 95-140 is <scene name='Sandbox6_Eric_Martz/83-341_hydrophobic/1'>partially hydrophobic</scene>. Bear in mind that sidechain positions are incorrect in a homology model. <scene name='Sandbox6_Eric_Martz/83-341_hydrophobic/2'>Hide 141-341</scene>. The distribution of hydrophobic residues in 83-140 of the homology model is similar to that in the <scene name='Sandbox6_Eric_Martz/3e4c_147-205_hydrophobic/1'>corresponding residues 147-205 in the template 3e4c</scene>. * The inner face of 95-140 is <scene name='Sandbox6_Eric_Martz/83-341_conservation/1'>highly conserved</scene>, even based upon a multiple sequence alignment that includes mostly types other than 12<ref>ConSurf run using 80 sequences from the Uniref-90 sequence database. MSA average pairwise distance (APD) 0.94.</ref> <scene name='Sandbox6_Eric_Martz/83-341_conservation/2'>Hide 141-341</scene>. {{Template:ColorKey_ConSurf_NoGray}} * When the multiple sequence alignment is limited to the 14 type-12 sequences available from Uniprot (APD 0.30), most of the residues have insufficient data, but a <scene name='Sandbox6_Eric_Martz/83-341_conservation/3'>few on the outside face are highly conserved</scene>, namely Asn130, Val135, Val136, Glu139, Asn140. <scene name='Sandbox6_Eric_Martz/83-341_conservation/4'>Hide 141-341</scene>. The homology model can be downloaded from [[:Image:Caspase12-homology-model-83-341-on-3e4c-a.pdb|homology-model-83-341]]. <references />

• Template:ColorKey Amino2CarboxyRainbow
• Template:ColorKey Charge Anionic
• Template:ColorKey Charge Cationic
• Template:ColorKey ConSurf NoGray

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