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{{STRUCTURE_1he2 | PDB=1he2 | SIZE=400 | SCENE= | CAPTION=Human flavin reductase complex with biliverdin IX α and NADP [[1he2]] }} <!-- Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. Or use the four-green-boxes-button to insert scrollable text adjacent to a Jmol applet. Check out the other buttons as well! --> '''Flavin reductase''' (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. This reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. FR is involved in heme catabolism. ==3D structures of flavin reductase== [[1qfj]] – FR – ''Escherichia coli''<br /> [[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br /> [[2bkj]] - VhFR + NAD + FMN<br /> [[1hdo]] - hFR + NADP - human<br /> [[1he2]] - hFR + biliverdin IX α + NADP<BR /> [[1he3]] - hFR + mesobiliverdin IV α + NADP<BR /> [[1he4]] - hFR + FMN + NADP<BR /> [[1he5]] - hFR + lumichrome + NADP<BR /> [[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br /> [[1rz1]] - GtFR + FAD + NAD<br /> [[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''

• Template:ColorKey Hydrophobic
• Template:ColorKey Polar
• Template:MONTHNAME (protected)
• Template:MONTHNUMBER (protected)

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