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<applet load="1eve" size="400" color="white" frame="true" align="right" spinBox="true" script="1eve/E2020_in_ache/6" caption="PDB: 1eve, resolution 2.50&Aring;" /> <big>Welcome to Proteopedia,</big> The collaborative, 3D encyclopedia of proteins and other molecules. ===Green links change the 3D image!=== <big>''Here's an excerpt from one of our pages:''</big> The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a '''<scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene>''' along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>. ---- ===See more!=== Here are three of our favorite pages. Visit them to get a feeling for Proteopedia: * [[Hemoglobin]] * [[1eve | Acetylcholinesterase with the anti-Alzheimer's drug Aricept bound]] * [[1v04 | Serum Paraoxonase-1 created by directed evolution]]. ====Browse!==== * [[Special:Popularpages | Most-popular pages]] * [[Special:Mostrevisions | Most-revised pages]] * [[Special:Longpages | Longest pages]] * [[Special:Newpages | Newest pages]] ---- ===How can I find my protein/molecule?=== Search Proteopedia using the search box in the toolbar to the left. ===Want to contribute?=== We encourage you to '''edit pages freely''' (you need a user account to edit at the moment, so ask us for one). '''To request a user account''', email '''eran.hodis''' ''at'' '''weizmann.ac.il''' These resources may help you familiarize yourself with the editing process. Trust us, the editing process is very simple: All text is edited the same way that Wikipedia is edited, so it must be easy! And all scenes are created using our user-friendly ''Scene authoring tools''. Of course it helps to familiarize yourself with the site and how to go about editing, so check out these resources: *A video capture of making a Proteopedia page in 4 minutes [http://www.proteopedia.org/support/ProteopediaEditing4min.mov here] (~400mb). *A rough and temporary tutorial available [http://www.proteopedia.org/support/ProteopediaTempTut.mov here] (~235mb). *The [[Help:Editing | editing help page]]. *The help page for the [[Scene authoring tools]]. ---- ===Proteopedia Mission Statement=== To collect and disseminate structural biological and biological knowledge about proteins, RNA, DNA, and their assemblies and interacting small molecules in a manner that is relevant and accessible to scientists of all the biological and chemical fields. ===Goals for Proteopedia=== * To serve as a forum for scientists to share, retrieve and discuss information related to proteins, macromolecules, and small molecules and chemicals of interest. * To continue to develop the concept of tying text to three-dimensional, interactive images. * To maintain low barriers for contribution.

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