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<StructureSection load='4gky' size='450' side='right' caption='Human ERGIC-53 carbohydrate recognition domain complex with mannose (stick model), glycerol and Ca+2 ion (green) (PDB code [[4gky]])' scene='74/748868/Cv/1'> == Function == '''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. == Relevance == Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. == Structural highlights == ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/2'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>. </StructureSection> ==3D structures of ERGIC-53== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} [[4ygb]], [[4ygc]], [[4ygd]], [[4yge]], [[3wht]], [[3lcp]], [[3a4u]] – hERGIC-53 CRD domain + MCFD2 + Ca - human<br /> [[3whu]], [[3wnx]] – hERGIC-53 CRD domain + MCFD2 + Ca + mannose<br /> [[4gkx]] – hERGIC-53 CRD domain + Ca <br /> [[4gky]] – hERGIC-53 CRD domain + Ca + mannose<br /> [[1r1z]] – rERGIC-53 CRD domain + Ca - rat<br /> [[1gv9]] – rERGIC-53 CRD domain <br /> == References == <references/>

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