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<StructureSection load='1ads' size='400' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1ads]])' scene='43/436098/Cv/2'> == Function == [[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.<ref>PMID:1734286</ref> == Disease == The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. == Structural highlights == AldR structure is of a <scene name='43/436098/Cv/3'>β/α-barrel</scene>. The <scene name='43/436098/Cv/8'>active site is located in the barrel core</scene>.<ref>PMID:1621098</ref> *<scene name='43/436098/Cv/7'>Active site interactions</scene>. Water molecules are shown as red spheres. *<scene name='43/436098/Cv/9'>Active site tunnel</scene>. == 3D Structures of aldose reductase == [[Aldose reductase 3D structures]] </StructureSection> == References == <references/> [[Category:Topic Page]]

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