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<StructureSection load='1q1c' size='350' side='right' scene='' caption='Human FKBP52 N-terminal complex with ethylene glycol and DMSO (PDB code [[1q1c]]) '> [[Image:1q1c.png|left|200px]] ===Crystal structure of N-terminus of human FKBP52 ([[1q1c]])=== '''(see also [[FK506 binding protein]])''' {{ABSTRACT_PUBMED_15159550}} {{Clear}} The 3D structures of several FKBP family members from various species are solved, most of them comprise 1-2 FK domains (''e.g.'' human FKBP52), while wFKBP73 (''e.g.'' [[3jym]]) has 3 FK domains which is characteristic to plants. A sequence-based structure comparison between each of the 3 FK domains of wFKBP73 ([[3jym]]) and the 2 FK domains of hFKBP52 ([[1q1c]]) was performed. All 3 FK domains of wFKBP73 adopt a typical FK fold exhibiting significant diversity when superimposed. They are arranged in a linear manner in space as observed in the 2 FK domains of hFKBP52. While the 2 FK domains of hFKBP52 are in the same orientation, the orientation between any 2 consecutive wFK73 domains is different than that between the two FK domains of hFKBP52. <scene name='3jym/Al/2'>Superposition</scene> of the <font color='blueviolet'><b>wFK73_1 (in blueviolet)</b></font> and <font color='cyan'><b>wFK73_2 (in cyan)</b></font> domains ([[3jym]]) on hFK52_1 (in yellow) and <font color='blue'><b>hFK52_2 (in blue)</b></font> revealed that while <font color='cyan'><b>wFK73_2</b></font> is perfectly aligned with <font color='blue'><b>hFK52_2</b></font>, N-terminal <font color='blueviolet'><b>wFK73_1</b></font> does not align with hFK52_1 (yellow). Similarly, <scene name='3jym/Al/3'>superposition</scene> of the <font color='cyan'><b>wFK73_2</b></font> and <font color='magenta'><b>wFK73_3 (in magenta)</b></font> domains on hFKBP52 revealed that while <font color='cyan'><b>wFK73_2</b></font> is perfectly aligned with hFK52_1 (in yellow), <font color='magenta'><b>wFK73_3</b></font> does not align with <font color='blue'><b>hFK52_2</b></font>. This unique arrangement of wFKBP73 causes that the α-helices of <scene name='3jym/Al/4'>wFKBP73 3 FK domains</scene> are exposed on the same surface, while the <scene name='3jym/Al/5'>2 α-helices of hFK52</scene> are presented on opposite surfaces. ==About this Structure== 1Q1C is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1C OCA]. </StructureSection> ==References== <ref group="xtra">PMID:15159550</ref> <ref group="xtra">PMID:20306145</ref><references group="xtra"/> [[Category:Topic Page]] [[Category: Homo sapiens]] [[Category: Peptidylprolyl isomerase]] [[Category: Ding, Y.]] [[Category: Li, P.]] [[Category: Lou, Z.]] [[Category: Rao, Z.]] [[Category: Shen, B.]] [[Category: Shu, C.]] [[Category: Wu, B.]] [[Category: Nuclear protein]] [[Category: Phosphorylation]] [[Category: Rotamase]] [[Category: Tpr repeat]]

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