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{{Article under development}} NEEDS UPDATING TO INCLUDE [[4ay9]]. [[Image:1xwd polyview3d.png|left|400px]] ===Crystal Structure of Human Follicle-Stimulating Hormone Complexed with its Receptor=== <!-- The line below this paragraph, {{ABSTRACT_PUBMED_15662415}}, adds the Publication Abstract to the page (as it appears on PubMed at http://www.pubmed.gov), where 15662415 is the PubMed ID number. --> {{ABSTRACT_PUBMED_15662415}} ==Disease== <!-- The line below this paragraph, containing "STRUCTURE_1xwd", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PDB file loaded into the applet) or the SCENE parameter (which sets the initial scene displayed when the page is loaded), or leave the SCENE parameter empty for the default display. --> <!--TURNS OUT IF YOU SET PDB TO NOTHING YOU CAN GET RID OF COORDINATES BLOCK AND HAVE BOLD CAPTION!!--> <table width=380' align='right' cellpadding='0'><tr><td bgcolor='#eeeeee'>{{Structure |PDB= |SIZE=350|SCENE=Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4|CAPTION= Glycosylated FSH complex with acetylamino-deoxy-pyranose and sulfate binding to the leucine-rich domain of Follicle Stimulating Hormone Receptor ([[1fl7]] morphing to [[1xwd]], [[resolution]] 2.92&Aring;) |SITE= |LIGAND= |ACTIVITY= |GENE= |DOMAIN= |RELATEDENTRY= |RESOURCES= |COORDINATES= }}</td></tr><tr><td bgcolor='#eeeeee'><center> {{Button ColorReceptorLeucine}} <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorph/4'>Initial scene</scene> </center></td></tr></table> Known disease associated with this structure: Follicle-stimulating hormone deficiency, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136530 136530]], Ovarian dysgenesis 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian hyperstimulation syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian response to FSH stimulation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]], Ovarian sex cord tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=136435 136435]] ==About this Structure== 1XWD is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWD OCA]. The leucine-rich domain of the receptor <scene name='Human_Follicle-Stimulating_Hormone_Complexed_with_its_Receptor/1fl7to1xwdmorphleu/4'>has a characteristic bowed shape due to harboring a series of leucine-rich repeats</scene>; [[Leucine-rich repeat|leucine-rich repeats]] often are horseshoe- or arc-shaped.<br\> {{Button Toggle AnimationOnPause}}<br\> {{Link Toggle WireframeOnOff}}<br\> {{Link Toggle FancyCartoonHighQualityView}}<br\> Add about cysteine-knot. <br\> Add about seat belt.<br\> Keep in mind this is just the leucine-rich repeat, amino-terminal portion of the receptor and that in the full receptor structure part of the chain also forms a [[G protein-coupled receptor]] and a brief intracellular domain at the C-terminus. ==References== <ref group="xtra">PMID:15662415</ref><references group="xtra"/> <ref group="xtra">PMID:22802634 </ref><references group="xtra"/> ==See also== *[[Leucine-rich repeat|Leucine-rich repeat proteins]] * [[Hormone]] * [[Membrane proteins]] *[[Receptor]] *[[Transmembrane (cell surface) receptors]] *[[G protein-coupled receptors]] * [[1hcn]] - human chorionic gonadotropin placental hormone * [[1hrp]] - human chorionic gonadotropin placental hormone * [[1hd4]] - human chorionic gonadotropin placental hormone alpha subunit * [[3g04]] - Human thyroid-stimulating hormone receptor in complex with a thyroid-stimulating autoantibody ==3D structures of follicle-stimulating hormone== See [[Follicle-stimulating hormone]] ==External Resources== * [http://www.ssfa-gphr.de/index.php Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors] * [http://gris.ulb.ac.be/ GRIS: Glycoprotein-hormone Receptors Information System] [[Category: Homo sapiens]] [[Category: Fan, Q R.]] [[Category: Hendrickson, W A.]] [[Category: Cysteine-knot motif]] [[Category: Hormone-receptor complex]] [[Category: Leucine-rich repeat]] [[Category:Topic Page]] ''Page originally seeded at [[1xwd]] by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:34:49 2009''

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