1av5
From Proteopedia
(New page: 200px<br /> <applet load="1av5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1av5, resolution 2.0Å" /> '''PKCI-SUBSTRATE ANALO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AV5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with AP2 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AV5 OCA]]. | + | 1AV5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with AP2 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: AVA, AVB, HNA and HNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AV5 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: protein kinase inhibitor]] | [[Category: protein kinase inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:43:40 2007'' |
Revision as of 06:38, 30 October 2007
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PKCI-SUBSTRATE ANALOG
Overview
The histidine triad (HIT) protein family is among the most ubiquitous and, highly conserved in nature, but a biological activity has not yet been, identified for any member of the HIT family. Fragile histidine triad, protein (FHIT) and protein kinase C interacting protein (PKCI) were used, in a structure-based approach to elucidate characteristics of in vivo, ligands and reactions. Crystallographic structures of apo, substrate, analog, pentacovalent transition-state analog, and product states of both, enzymes reveal a catalytic mechanism and define substrate characteristics, required for catalysis, thus unifying the HIT family as nucleotidyl, hydrolases, transferases, or both. The approach described here may be, useful in identifying structure-function relations between protein, families ... [(full description)]
About this Structure
1AV5 is a [Single protein] structure of sequence from [Homo sapiens] with AP2 as [ligand]. Structure known Active Sites: AVA, AVB, HNA and HNB. Full crystallographic information is available from [OCA].
Reference
Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207
Page seeded by OCA on Tue Oct 30 08:43:40 2007
