1c7k
From Proteopedia
(New page: 200px<br /> <applet load="1c7k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c7k, resolution 1.00Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1C7K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C7K OCA]]. | + | 1C7K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: ZIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C7K OCA]]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: metalloproteinase]] | [[Category: metalloproteinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:44:32 2007'' |
Revision as of 06:39, 30 October 2007
|
CRYSTAL STRUCTURE OF THE ZINC PROTEASE
Overview
A zinc endoprotease produced by Streptomyces caespitosus (ScNP) contains a, H83E84TGH87VLG90LPD93-Met103 sequence. Except for D93, this amino acid, sequence is the same as a characteristic consensus HEXXHXXGXXH-M motif, found in one class of zinc endoprotease called 'metzincins'. We analyzed, the structural and functional role of the consensus sequence located, around a catalytically essential zinc ion based on the crystal structure, of ScNP. The structure was determined at the highest level on resolution, (1 A resolution) and accuracy among crystal structures of zinc, endoproteases ever determined. The zinc ion of ScNP is tetrahedrally, coordinated by three amino acid side-chains (H83, H87 and D93) and a water, molecule. The distances between the zinc ion and the coordinating atoms, are ... [(full description)]
About this Structure
1C7K is a [Single protein] structure of sequence from [[1]] with ZN and CA as [ligands]. Structure known Active Site: ZIN. Full crystallographic information is available from [OCA].
Reference
Structure of the zinc-binding site in the crystal structure of a zinc endoprotease from Streptomyces caespitosus at 1 A resolution., Kurisu G, Kai Y, Harada S, J Inorg Biochem. 2000 Nov;82(1-4):225-8. PMID:11132632
Page seeded by OCA on Tue Oct 30 08:44:32 2007
