This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1c7k
From Proteopedia
(New page: 200px<br /> <applet load="1c7k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c7k, resolution 1.00Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1C7K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C7K OCA]]. | + | 1C7K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: ZIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C7K OCA]]. |
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: metalloproteinase]] | [[Category: metalloproteinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:44:32 2007'' |
Revision as of 06:39, 30 October 2007
|
CRYSTAL STRUCTURE OF THE ZINC PROTEASE
Overview
A zinc endoprotease produced by Streptomyces caespitosus (ScNP) contains a, H83E84TGH87VLG90LPD93-Met103 sequence. Except for D93, this amino acid, sequence is the same as a characteristic consensus HEXXHXXGXXH-M motif, found in one class of zinc endoprotease called 'metzincins'. We analyzed, the structural and functional role of the consensus sequence located, around a catalytically essential zinc ion based on the crystal structure, of ScNP. The structure was determined at the highest level on resolution, (1 A resolution) and accuracy among crystal structures of zinc, endoproteases ever determined. The zinc ion of ScNP is tetrahedrally, coordinated by three amino acid side-chains (H83, H87 and D93) and a water, molecule. The distances between the zinc ion and the coordinating atoms, are ... [(full description)]
About this Structure
1C7K is a [Single protein] structure of sequence from [[1]] with ZN and CA as [ligands]. Structure known Active Site: ZIN. Full crystallographic information is available from [OCA].
Reference
Structure of the zinc-binding site in the crystal structure of a zinc endoprotease from Streptomyces caespitosus at 1 A resolution., Kurisu G, Kai Y, Harada S, J Inorg Biochem. 2000 Nov;82(1-4):225-8. PMID:11132632
Page seeded by OCA on Tue Oct 30 08:44:32 2007
