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2bgn
From Proteopedia
(New page: 200px<br /> <applet load="2bgn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bgn, resolution 3.15Å" /> '''HIV-1 TAT PROTEIN D...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BGN is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGN OCA]]. | + | 2BGN is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Hydrolase Hydrolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BGN OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:45:28 2007'' |
Revision as of 06:40, 30 October 2007
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HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE TRP2-TAT (1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)
Overview
CD26 or dipeptidyl-peptidase IV (DPPIV) is engaged in immune functions by, co-stimulatory effects on activation and proliferation of T lymphocytes, binding to adenosine deaminase, and regulation of various chemokines and, cytokines. DPPIV peptidase activity is inhibited by both Tat protein from, human immunodeficiency virus (HIV)-1 and its N-terminal nonapeptide, Tat-(1-9) with amino acid sequence MDPVDPNIE, suggesting that DPPIV, mediates immunosuppressive effects of Tat protein. The 2.0- and 3.15-A, resolution crystal structures of the binary complex between human DPPIV, and nonapeptide Tat-(1-9) and the ternary complex between the variant, MWPVDPNIE, called Trp(2)-Tat-(1-9), and DPPIV bound to adenosine deaminase, show that Tat-(1-9) and Trp(2)-Tat-(1-9) are located in the active site ... [(full description)]
About this Structure
2BGN is a [Protein complex] structure of sequences from [Homo sapiens] with NAG and ZN as [ligands]. Active as [Hydrolase], with EC number [3.4.14.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26)., Weihofen WA, Liu J, Reutter W, Saenger W, Fan H, J Biol Chem. 2005 Apr 15;280(15):14911-7. Epub 2005 Jan 28. PMID:15695814
Page seeded by OCA on Tue Oct 30 08:45:28 2007
Categories: Homo sapiens | Protein complex | Fan, H. | Liu, J. | Reutter, W. | Saenger, W. | Weihofen, W.A. | NAG | ZN | Ada | Adenosine deaminase | Alpha/beta-hydrolase fold | Aminopeptidase | Beta-propeller fold | Cd26 | Dipetidyl peptidase iv | Dppiv | Hiv-1 tat protein | Protein-protein complex | Serine protease
