1hkv
From Proteopedia
(New page: 200px<br /> <applet load="1hkv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hkv, resolution 2.60Å" /> '''MYCOBACTERIUM DIAMI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HKV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with LYS and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKV OCA]]. | + | 1HKV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]] with LYS and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Lyase Lyase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20]]. Structure known Active Site: PLA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HKV OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tbsgc]] | [[Category: tbsgc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:46:38 2007'' |
Revision as of 06:41, 30 October 2007
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MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LYSA)
Overview
The Mycobacterium tuberculosis lysA gene encodes the enzyme, meso-diaminopimelate decarboxylase (DAPDC), a pyridoxal-5'-phosphate, (PLP)-dependent enzyme. The enzyme catalyzes the final step in the lysine, biosynthetic pathway converting meso-diaminopimelic acid (DAP) to, l-lysine. The lysA gene of M. tuberculosis H37Rv has been established as, essential for bacterial survival in immunocompromised mice, demonstrating, that de novo biosynthesis of lysine is essential for in vivo viability., Drugs targeted against DAPDC could be efficient anti-tuberculosis drugs, and the three-dimensional structure of DAPDC from M. tuberculosis, complexed with reaction product lysine and the ternary complex with PLP, and lysine in the active site has been determined. The first structure of, a DAPDC confirms ... [(full description)]
About this Structure
1HKV is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with LYS and PLP as [ligands]. Active as [Lyase], with EC number [4.1.1.20]. Structure known Active Site: PLA. Full crystallographic information is available from [OCA].
Reference
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis., Gokulan K, Rupp B, Pavelka MS Jr, Jacobs WR Jr, Sacchettini JC, J Biol Chem. 2003 May 16;278(20):18588-96. Epub 2003 Mar 10. PMID:12637582
Page seeded by OCA on Tue Oct 30 08:46:38 2007
Categories: Mycobacterium tuberculosis | Single protein | Gokulan, K. | Junior, M.S.Pavelka. | Junior, W.R.Jacobs. | Rupp, B. | Sacchettini, J.C. | TBSGC, TB.Structural.Genomics.Consortium. | LYS | PLP | Dapdc | Decarboxylase | Diaminopimelate | Lyase | Lysine pathway | Lysine synthetic pathway | Mycbacterium tuberculosis | Plp | Protein structure initiative | Psi | Pyridoxal phosphate | Tb | Tb structural genomics consortium | Tbsgc
