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8gpb
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 8GPB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with PLP and AMP as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 8GPB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb24_1.html Glycogen Phosphorylase]]. Full crystallographic information is available from | + | 8GPB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with PLP and AMP as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 8GPB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb24_1.html Glycogen Phosphorylase]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=8GPB OCA]]. |
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==Reference== | ==Reference== | ||
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[[Category: glycogen phosphorylase]] | [[Category: glycogen phosphorylase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 18:03: | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Oct 28 18:03:49 2007'' |
Revision as of 15:59, 28 October 2007
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STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP
Overview
The crystal structures of activated R state glycogen phosphorylase a (GPa), and R and T state glycogen phosphorylase b (GPb) complexed with AMP have, been solved at 2.9 A, 2.9 A and 2.2 A resolution, respectively. The, structure of R state GPa is nearly identical to the structure of, sulphate-activated R state GPb, except in the region of Ser14, where there, is a covalently attached phosphate group in GPa and a non-covalently, attached sulphate group in GPb. The contacts made by the N-terminal tail, residues in R state GPa at the subunit interface of the functionally, active dimer are similar to those observed previously for T state GPa. The, quaternary and tertiary structural changes on the T to R transition allow, these interactions to be relayed to the catalytic site in R state GPa. ... [(full description)]
About this Structure
8GPB is a [Single protein] structure of sequence from [Oryctolagus cuniculus] with PLP and AMP as [ligands]. The following page contains interesting information on the relation of 8GPB with [Glycogen Phosphorylase]. Full crystallographic information is available from [OCA].
Reference
Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP., Barford D, Hu SH, Johnson LN, J Mol Biol. 1991 Mar 5;218(1):233-60. PMID:1900534
Page seeded by OCA on Sun Oct 28 18:03:49 2007
