Nathan Line sandbox 1

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(→The Mechanism of Trypsin)
(→The Mechanism of Trypsin)
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The peptide is pulled into the active site by Asp 189. His 57 pulls on the hydrogen attached to the OH on Ser 195 to make it a better nucleophilie which attacks the carbonyl of the peptide. This tetrahedral intermediate removes the hydrogen from His 57 while the carbonyl reforms resulting in a break in the peptide backbone. After the amino group is replaced with water, the water again attacks the carbonyl and this tetrahedral collapses to reconstruct both the Ser195 and His57. The final products result in an amino group and a carboxylic acid compound.
The peptide is pulled into the active site by Asp 189. His 57 pulls on the hydrogen attached to the OH on Ser 195 to make it a better nucleophilie which attacks the carbonyl of the peptide. This tetrahedral intermediate removes the hydrogen from His 57 while the carbonyl reforms resulting in a break in the peptide backbone. After the amino group is replaced with water, the water again attacks the carbonyl and this tetrahedral collapses to reconstruct both the Ser195 and His57. The final products result in an amino group and a carboxylic acid compound.
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{{STRUCTURE_2ah4 | PDB=2ah4 | SCENE= }}
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{{STRUCTURE_3cin | PDB=3cin | SCENE= }}
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Revision as of 14:44, 19 February 2010

The Mechanism of Trypsin

The peptide is pulled into the active site by Asp 189. His 57 pulls on the hydrogen attached to the OH on Ser 195 to make it a better nucleophilie which attacks the carbonyl of the peptide. This tetrahedral intermediate removes the hydrogen from His 57 while the carbonyl reforms resulting in a break in the peptide backbone. After the amino group is replaced with water, the water again attacks the carbonyl and this tetrahedral collapses to reconstruct both the Ser195 and His57. The final products result in an amino group and a carboxylic acid compound.


PDB ID 2ah4

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2ah4, resolution 1.13Å ()
Ligands: , ,
Activity: Trypsin, with EC number 3.4.21.4
Related: 2age, 2agg, 2agi
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


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Nathan Line

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