Acetylcholine
From Proteopedia
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<applet load='ACHE2.pdb' size='500' frame='true' align='right' | <applet load='ACHE2.pdb' size='500' frame='true' align='right' | ||
| - | scene='2ace/Ach/ | + | scene='2ace/Ach/4' /> |
| - | [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Ach/4'>(ACh)</scene>, producing <scene name='2ace/Ach/5'>choline and an acetate</scene> group. <scene name='2ace/Ach/4'>ACh</scene> directly binds <scene name='2ace/Ach/11'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Ach/12'>(Ser200, His440, and Glu327)</scene> | + | [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase] [http://en.wikipedia.org/wiki/Hydrolysis hydrolysizes] the [http://en.wikipedia.org/wiki/Neurotransmitter neurotransmitter] [http://en.wikipedia.org/wiki/Acetylcholine acetylcholine] <scene name='2ace/Ach/4'>(ACh)</scene>, producing <scene name='2ace/Ach/5'>choline and an acetate</scene> group. <scene name='2ace/Ach/4'>ACh</scene> directly binds <scene name='2ace/Ach/11'>Ser200</scene> (via its [http://en.wikipedia.org/wiki/Nucleophile nucleophilic] Oγ atom) within the [http://en.wikipedia.org/wiki/Catalytic_triad catalytic triad] <scene name='2ace/Ach/12'>(Ser200, His440, and Glu327)</scene> of [http://en.wikipedia.org/wiki/Pacific_electric_ray ''Torpedo californica''] [[acetylcholinesterase]] (''Tc''AChE structure [[2ace]]). The residues <scene name='2ace/Ach/13'>Trp84 and Phe330</scene> are also important in the [http://en.wikipedia.org/wiki/Ligand ligand] recognition. |
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Revision as of 08:37, 2 March 2010
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Acetylcholine at the Wikipedia
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Acetylcholinesterase hydrolysizes the neurotransmitter acetylcholine , producing group. directly binds (via its nucleophilic Oγ atom) within the catalytic triad of Torpedo californica acetylcholinesterase (TcAChE structure 2ace). The residues are also important in the ligand recognition.
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, David Canner, Joel L. Sussman, Ralf Stephan, Harry Greenblatt
