Collagen Structure & Function
From Proteopedia
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The molecule itself is approxiametly 1-2nm in diameter and 300nm in length. | The molecule itself is approxiametly 1-2nm in diameter and 300nm in length. | ||
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There are currently close to 30 different types of collagen that have been identified. The most abundant type of collagen present in the human body is that of Type I with significant amounts of Type II,III and IV also accounted for. | There are currently close to 30 different types of collagen that have been identified. The most abundant type of collagen present in the human body is that of Type I with significant amounts of Type II,III and IV also accounted for. | ||
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*Type IV-found in the basement membrane of cell membranes | *Type IV-found in the basement membrane of cell membranes | ||
*Type V-found in hair | *Type V-found in hair | ||
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| + | ==Collagen-Related Disorders= | ||
| + | There are many types of disorders associated with collagen. These include: | ||
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| + | ==References== | ||
| + | Bella J, Eaton M, Brodsky B, Berman HM ''Crystal and molecular structure of a collagen-like peptide at 1.9A resolution'' Science v266, p.75-81 | ||
{{STRUCTURE_1cag | PDB=1cag | SCENE= }} | {{STRUCTURE_1cag | PDB=1cag | SCENE= }} | ||
Revision as of 01:56, 22 March 2010
Contents |
Collagen
Introduction
Collagen is a member of a naturally occurring protein family. In nature is is found in animals and is responsible for a variety of biological functions.
Molecular Structure
Collagen takes the form of a triple helix which is stabilized by hydrogen bonding. Each of it's alpha-helices are enclosed by a hydration cylinder. The molecule itself is approxiametly 1-2nm in diameter and 300nm in length.
Function
There are currently close to 30 different types of collagen that have been identified. The most abundant type of collagen present in the human body is that of Type I with significant amounts of Type II,III and IV also accounted for.
- Type I- found in bones,tendons,organs
- Type II-found mainly in cartilage
- Type III-found mainly in reticular fibres
- Type IV-found in the basement membrane of cell membranes
- Type V-found in hair
=Collagen-Related Disorders
There are many types of disorders associated with collagen. These include:
References
Bella J, Eaton M, Brodsky B, Berman HM Crystal and molecular structure of a collagen-like peptide at 1.9A resolution Science v266, p.75-81
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| 1cag, resolution 1.85Å () | |||||||
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| Ligands: | |||||||
| Non-Standard Residues: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
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Daman K. Kandola, Alexander Berchansky, David Canner, Andrea Gorrell, Luis Netto
