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Prolyl Endopeptidase

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<applet load='1yr2' size='300' frame='true' align='right' caption='Prolyl endopeptidase of Sphingomonas capsulata' />
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Prolyl endopeptidases (PEPs) are a class of serine proteases which cleave peptide bonds on the c-terminal side of internal proline residues. Proline residues are often stable to proteases due to their unique structure and even PEPs require a trans peptide bond preceeding proline for hydrolysis to occur.
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Prolyl endopeptidases (PEPs) are a class of serine proteases which cleave peptide bonds on the c-terminal side of internal proline residues.
== Structure ==
== Structure ==

Revision as of 19:56, 24 March 2010

Prolyl endopeptidase of Sphingomonas capsulata

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Prolyl endopeptidases (PEPs) are a class of serine proteases which cleave peptide bonds on the c-terminal side of internal proline residues.

Contents

Structure

β-Propeller Domain

Catalytic Domain

Domain Interface

Function

Binding Mechanism

Inhibition

Pharmaceutical Possibilities

Celiac Disease

Neurological Disorders

References

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