3dv1

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==About this Structure==
==About this Structure==
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3DV1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DV1 OCA].
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3DV1 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DV1 OCA].
==Reference==
==Reference==
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Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo., Machauer R, Laumen K, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Jaton AL, Desrayaud S, Staufenbiel M, Rabe S, Paganetti P, Neumann U, Bioorg Med Chem Lett. 2009 Mar 1;19(5):1366-70. Epub 2009 Jan 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19195887 19195887]
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<ref group="xtra">PMID:19195887</ref><ref group="xtra">PMID:19195886</ref><references group="xtra"/>
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Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors., Machauer R, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Neumann U, Paganetti P, Bioorg Med Chem Lett. 2009 Mar 1;19(5):1361-5. Epub 2009 Jan 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19195886 19195886]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
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[[Category: Single protein]]
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[[Category: Rondeau, J M.]]
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[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
[[Category: Alzheimer's disease]]
[[Category: Alzheimer's disease]]
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[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 20:17:18 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:04:47 2010''

Revision as of 07:04, 7 April 2010

Image:3dv1.png

Template:STRUCTURE 3dv1

Crystal structure of human beta-secretase in complex with NVP-ARV999

Template:ABSTRACT PUBMED 19195887

About this Structure

3DV1 is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Machauer R, Laumen K, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Jaton AL, Desrayaud S, Staufenbiel M, Rabe S, Paganetti P, Neumann U. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1366-70. Epub 2009 Jan 22. PMID:19195887 doi:10.1016/j.bmcl.2009.01.055
  • Machauer R, Veenstra S, Rondeau JM, Tintelnot-Blomley M, Betschart C, Neumann U, Paganetti P. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1361-5. Epub 2009 Jan 19. PMID:19195886 doi:10.1016/j.bmcl.2009.01.036

Page seeded by OCA on Wed Apr 7 10:04:47 2010

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