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1h75
From Proteopedia
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Revision as of 08:23, 30 October 2007
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STRUCTURAL BASIS FOR THE THIOREDOXIN-LIKE ACTIVITY PROFILE OF THE GLUTAREDOXIN-LIKE PROTEIN NRDH-REDOXIN FROM ESCHERICHIA COLI.
Overview
NrdH-redoxin is a representative of a class of small redox proteins that, contain a conserved CXXC motif and are characterized by a, glutaredoxin-like amino acid sequence and thioredoxin-like activity, profile. The crystal structure of recombinant Escherichia coli, NrdH-redoxin in the oxidized state has been determined at 1.7 A resolution, by multiwavelength anomalous diffraction. NrdH-redoxin belongs to the, thioredoxin superfamily and is structurally most similar to E. coli, glutaredoxin 3 and phage T4 glutaredoxin. The angle between the C-terminal, helix alpha3 and strand beta4, which differs between thioredoxin and, glutaredoxin, has an intermediate value in NrdH-redoxin. The orientation, of this helix is to a large extent determined by an extended hydrogen-bond, network involving the ... [(full description)]
About this Structure
1H75 is a [Single protein] structure of sequence from [Escherichia coli]. Structure known Active Site: DIS. Full crystallographic information is available from [OCA].
Reference
Structural basis for the thioredoxin-like activity profile of the glutaredoxin-like NrdH-redoxin from Escherichia coli., Stehr M, Schneider G, Aslund F, Holmgren A, Lindqvist Y, J Biol Chem. 2001 Sep 21;276(38):35836-41. Epub 2001 Jul 5. PMID:11441020
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