1qo8
From Proteopedia
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1QO8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shewanella_frigidimarina Shewanella frigidimarina]] with HEM and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1QO8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Shewanella_frigidimarina Shewanella frigidimarina]] with HEM and FAD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1]]. Structure known Active Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9 and BC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QO8 OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Shewanella frigidimarina]] | [[Category: Shewanella frigidimarina]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Succinate dehydrogenase]] | ||
[[Category: Bamford, V.]] | [[Category: Bamford, V.]] | ||
[[Category: Dobbin, P.S.]] | [[Category: Dobbin, P.S.]] | ||
| Line 22: | Line 23: | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:37:05 2007'' |
Revision as of 08:32, 30 October 2007
|
THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE
Overview
Fumarate reductases and succinate dehydrogenases play central roles in the, metabolism of eukaryotic and prokaryotic cells. A recent medium resolution, structure of the Escherichia coli fumarate reductase (Frd) has revealed, the overall organization of the membrane-bound complex. Here we present, the first high resolution X-ray crystal structure of a water-soluble, bacterial fumarate reductase in an open conformation. This structure, reveals a mobile domain that modulates substrate access to the active site, and provides new insights into the mechanism of this widespread and, important family of FAD-containing respiratory proteins.
About this Structure
1QO8 is a [Single protein] structure of sequence from [Shewanella frigidimarina] with HEM and FAD as [ligands]. Active as [Succinate dehydrogenase], with EC number [1.3.99.1]. Structure known Active Sites: AC1, AC2, AC3, AC4, AC5, AC6, AC7, AC8, AC9 and BC1. Full crystallographic information is available from [OCA].
Reference
Open conformation of a flavocytochrome c3 fumarate reductase., Bamford V, Dobbin PS, Richardson DJ, Hemmings AM, Nat Struct Biol. 1999 Dec;6(12):1104-7. PMID:10581549
Page seeded by OCA on Tue Oct 30 10:37:05 2007
