Molecular playground/beta 2 microglobulin
From Proteopedia
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Banner: Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex, and in dialysis patients, it forms amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA). | Banner: Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex, and in dialysis patients, it forms amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA). | ||
| - | DRA is a complication of dialysis treatment in which these fibrils build up in joints causing pain and often eventually necessitating joint replacement. | + | DRA is a complication of dialysis treatment in which these fibrils build up in joints causing pain and often eventually necessitating joint replacement. beta-2-microglobulin can self-assemble into amyloid fibrils under physiological conditions in vitro when copper is present. |
Fibril assembly begins with the formation of a <scene name='User:Nick_Borotto/Sandbox_1/Proposed_dimer_structure/3'>Dimer</scene>. Dimer formation is initiated when copper binds near the <scene name='User:Nick_Borotto/Sandbox_1/Metal_coordination_site/4'>N-terminus</scene>, copper binding causes structural changes throughout the protein, creating two new <scene name='User:Nick_Borotto/Sandbox_1/Proposed_dimer_interface/4'>planes</scene>. These planes interact in an antiparallel fashion forming the dimer. | Fibril assembly begins with the formation of a <scene name='User:Nick_Borotto/Sandbox_1/Proposed_dimer_structure/3'>Dimer</scene>. Dimer formation is initiated when copper binds near the <scene name='User:Nick_Borotto/Sandbox_1/Metal_coordination_site/4'>N-terminus</scene>, copper binding causes structural changes throughout the protein, creating two new <scene name='User:Nick_Borotto/Sandbox_1/Proposed_dimer_interface/4'>planes</scene>. These planes interact in an antiparallel fashion forming the dimer. | ||
Revision as of 17:42, 12 May 2010
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Banner: Beta-2 microglobulin is a 12 kDa protein sub-unit of the class I major histocompatibility complex, and in dialysis patients, it forms amyloid fibrils in a condition known as dialysis-related amyloidosis (DRA).
DRA is a complication of dialysis treatment in which these fibrils build up in joints causing pain and often eventually necessitating joint replacement. beta-2-microglobulin can self-assemble into amyloid fibrils under physiological conditions in vitro when copper is present.
Fibril assembly begins with the formation of a . Dimer formation is initiated when copper binds near the , copper binding causes structural changes throughout the protein, creating two new . These planes interact in an antiparallel fashion forming the dimer.
