1v1j
From Proteopedia
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| - | [[Image:1v1j.gif|left|200px]]<br /> | + | [[Image:1v1j.gif|left|200px]]<br /><applet load="1v1j" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1v1j" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1v1j, resolution 2.2Å" /> | caption="1v1j, resolution 2.2Å" /> | ||
'''CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO'''<br /> | '''CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1V1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] with FA3 and TRS as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] | + | 1V1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] with FA3 and TRS as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] Known structural/functional Site: <scene name='pdbsite=DHQ:Trs Binding Site For Chain K'>DHQ</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1V1J OCA]. |
==Reference== | ==Reference== | ||
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[[Category: shikimate]] | [[Category: shikimate]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:21:50 2007'' |
Revision as of 16:12, 18 December 2007
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CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO
Overview
The fluoro analogue of the enolate intermediate in the reaction catalyzed, by type II dehydroquinases has been prepared from naturally occurring, (-)-quinic acid over seven steps and has been shown to be the most potent, inhibitor reported to date of the type II enzyme from Mycobacterium, tuberculosis.
About this Structure
1V1J is a Single protein structure of sequence from Streptomyces coelicolor with FA3 and TRS as ligands. Active as 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210
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