1w3c
From Proteopedia
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| - | [[Image:1w3c.gif|left|200px]]<br /> | + | [[Image:1w3c.gif|left|200px]]<br /><applet load="1w3c" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1w3c" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1w3c, resolution 2.3Å" /> | caption="1w3c, resolution 2.3Å" /> | ||
'''CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR'''<br /> | '''CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1W3C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses] with DN1 and DN2 as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1W3C is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Viruses Viruses] with DN1 and DN2 as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Dn2 Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W3C OCA]. |
==Reference== | ==Reference== | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:28:45 2007'' |
Revision as of 16:18, 18 December 2007
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR
Overview
The design of a series of peptidomimetic inhibitors of the hepatitis C, virus NS3 protease is described. These inhibitors feature an, indoline-2-carboxamide as a novel heterocyclic replacement for the P3, amino acid residue and N-terminal capping group of tripeptide based, inhibitors. The crystal structure of the ternary NS3/NS4A/inhibitor, complex for the most active molecule in this series highlights its, suitability as an N-terminal capping group of a dipeptide inhibitor of the, NS3 protease.
About this Structure
1W3C is a Single protein structure of sequence from Viruses with DN1 and DN2 as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease., Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkuhler C, Volpari C, Harper S, J Med Chem. 2004 Dec 16;47(26):6443-6. PMID:15588076
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