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3mpm

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3mpm.jpg|left|200px]]
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The entry 3mpm is ON HOLD
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{{STRUCTURE_3mpm| PDB=3mpm | SCENE= }}
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Authors: Cowan-Jacob, S.W., Rummel, G.
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===LCK complexed with a pyrazolopyrimidine===
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Description: LCK complexed with a pyrazolopyrimidine
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:46:30 2010''
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{{ABSTRACT_PUBMED_20483608}}
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==Disease==
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Known disease associated with this structure: SCID due to LCK deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153390 153390]]
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==About this Structure==
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3MPM is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPM OCA].
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==Reference==
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<ref group="xtra">PMID:20483608</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Cowan-Jacob, S W.]]
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[[Category: Rummel, G.]]
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[[Category: Kinase domain]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:33:28 2010''

Revision as of 04:29, 2 June 2010

Image:3mpm.jpg

Template:STRUCTURE 3mpm

Contents

LCK complexed with a pyrazolopyrimidine

Template:ABSTRACT PUBMED 20483608

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3MPM is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gommermann N, Buehlmayer P, von Matt A, Breitenstein W, Masuya K, Pirard B, Furet P, Cowan-Jacob SW, Weckbecker G. New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3628-31. Epub 2010 Apr 29. PMID:20483608 doi:10.1016/j.bmcl.2010.04.112

Page seeded by OCA on Wed Jun 2 08:33:28 2010

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