3lqr
From Proteopedia
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===Structure of CED-4:CED-3 complex=== | ===Structure of CED-4:CED-3 complex=== | ||
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==About this Structure== | ==About this Structure== | ||
3LQR is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQR OCA]. | 3LQR is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQR OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:20434985</ref><references group="xtra"/> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Pang, Y.]] | [[Category: Pang, Y.]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
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Revision as of 04:07, 16 June 2010
Structure of CED-4:CED-3 complex
The CED-4 homo-oligomer or apoptosome is required for initiation of programmed cell death in Caenorhabditis elegans by facilitating autocatalytic activation of the CED-3 caspase zymogen. How the CED-4 apoptosome assembles and activates CED-3 remains enigmatic. Here we report the crystal structure of the complete CED-4 apoptosome and show that it consists of eight CED-4 molecules, organized as a tetramer of an asymmetric dimer via a previously unreported interface among AAA(+) ATPases. These eight CED-4 molecules form a funnel-shaped structure. The mature CED-3 protease is monomeric in solution and forms an active holoenzyme with the CED-4 apoptosome, within which the protease activity of CED-3 is markedly stimulated. Unexpectedly, the octameric CED-4 apoptosome appears to bind only two, not eight, molecules of mature CED-3. The structure of the CED-4 apoptosome reveals shared principles for the NB-ARC family of AAA(+) ATPases and suggests a mechanism for the activation of CED-3.
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4., Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y, Cell. 2010 Apr 30;141(3):446-57. PMID:20434985
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3LQR is a 2 chains structure with sequences from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
- Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 2010 Apr 30;141(3):446-57. PMID:20434985 doi:10.1016/j.cell.2010.03.017
Page seeded by OCA on Wed Jun 16 08:11:54 2010
Categories: Caenorhabditis elegans | Pang, Y. | Qi, S. | Shi, Y. | Yan, N. | Alternative splicing | Apoptosis | Apoptosome | Atp-binding | Ced-3 | Ced-4 | Mitochondrion | Nucleotide-binding
