1c7k
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1C7K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ ]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: ZIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C7K OCA]]. | + | 1C7K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_caespitosus Streptomyces caespitosus]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: ZIN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C7K OCA]]. |
==Reference== | ==Reference== | ||
Structure of the zinc-binding site in the crystal structure of a zinc endoprotease from Streptomyces caespitosus at 1 A resolution., Kurisu G, Kai Y, Harada S, J Inorg Biochem. 2000 Nov;82(1-4):225-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11132632 11132632] | Structure of the zinc-binding site in the crystal structure of a zinc endoprotease from Streptomyces caespitosus at 1 A resolution., Kurisu G, Kai Y, Harada S, J Inorg Biochem. 2000 Nov;82(1-4):225-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11132632 11132632] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Streptomyces caespitosus]] | ||
[[Category: Harada, S.]] | [[Category: Harada, S.]] | ||
[[Category: Kai, Y.]] | [[Category: Kai, Y.]] | ||
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[[Category: metalloproteinase]] | [[Category: metalloproteinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:43:48 2007'' |
Revision as of 08:39, 30 October 2007
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CRYSTAL STRUCTURE OF THE ZINC PROTEASE
Overview
A zinc endoprotease produced by Streptomyces caespitosus (ScNP) contains a, H83E84TGH87VLG90LPD93-Met103 sequence. Except for D93, this amino acid, sequence is the same as a characteristic consensus HEXXHXXGXXH-M motif, found in one class of zinc endoprotease called 'metzincins'. We analyzed, the structural and functional role of the consensus sequence located, around a catalytically essential zinc ion based on the crystal structure, of ScNP. The structure was determined at the highest level on resolution, (1 A resolution) and accuracy among crystal structures of zinc, endoproteases ever determined. The zinc ion of ScNP is tetrahedrally, coordinated by three amino acid side-chains (H83, H87 and D93) and a water, molecule. The distances between the zinc ion and the coordinating atoms, are ... [(full description)]
About this Structure
1C7K is a [Single protein] structure of sequence from [Streptomyces caespitosus] with ZN and CA as [ligands]. Structure known Active Site: ZIN. Full crystallographic information is available from [OCA].
Reference
Structure of the zinc-binding site in the crystal structure of a zinc endoprotease from Streptomyces caespitosus at 1 A resolution., Kurisu G, Kai Y, Harada S, J Inorg Biochem. 2000 Nov;82(1-4):225-8. PMID:11132632
Page seeded by OCA on Tue Oct 30 10:43:48 2007
