User:Wayne Decatur/Sandbox Glutamate receptor
From Proteopedia
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kg2 OCA], [http://www.ebi.ac.uk/pdbsum/3kg2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3kg2 RCSB]</span> | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kg2 OCA], [http://www.ebi.ac.uk/pdbsum/3kg2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3kg2 RCSB]</span> | ||
}}[[3kg2]] is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG2 OCA]. | }}[[3kg2]] is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG2 OCA]. | ||
| + | The homomeric rat GluA2 receptor <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Default3kg2/1'>has four subunits that are arranged to form a 'Y'-shape</scene> with the <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Meas3kg2/1'>'top' being about three times the width of the 'bottom'</scene>. | ||
| + | ====Domains==== | ||
| + | The subunits themselves are modular <ref>PMID: 7539962</ref> and in the major domains are found in layers in the tetramer. | ||
| + | ::The 'top' layer is composed of the | ||
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<!-- select all; spacefill off; select hetero; color cpk; wireframe 0.35; spacefill 0.4; select zk1; spacefill on; color cpk; --> | <!-- select all; spacefill off; select hetero; color cpk; wireframe 0.35; spacefill 0.4; select zk1; spacefill on; color cpk; --> | ||
| - | To help give a better idea of how the glutamate receptor is oriented on the cell surface in the membrane lipid bilayer,<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/3kg2opm_mem/ | + | To help give a better idea of how the glutamate receptor is oriented on the cell surface in the membrane lipid bilayer,<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/3kg2opm_mem/10'>a slab representative of hydrophobic core of the lipid bilayer</scene> as calculated by the [http://opm.phar.umich.edu/protein.php?pdbid=3kg2 Orientations of Proteins in Membranes database](University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell. |
==PDB Entry== | ==PDB Entry== | ||
| - | [[3kg2]] is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG2 OCA]. | + | [[3kg2]] is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG2 OCA]. Although it is billed as the first structure of a full-length glutamate receptor, the carboxy-terminal domain is not present in the structure. |
| + | |||
| + | ==Reference for the structure== | ||
| + | <ref group="xtra">PMID:19946266</ref><references group="xtra"/> | ||
==Related Structures== | ==Related Structures== | ||
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* [[2a5t]] GluN1-GluN2A ligand-binding domain heterodimer | * [[2a5t]] GluN1-GluN2A ligand-binding domain heterodimer | ||
* [[2a5s]] GluN2A ligand-binding domain bound with glutamate | * [[2a5s]] GluN2A ligand-binding domain bound with glutamate | ||
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==See Also== | ==See Also== | ||
Revision as of 00:20, 4 July 2010
Contents |
AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775
Template:ABSTRACT PUBMED 19946266
About this Structure
| |||||||
| glutamate receptor (3kg2), resolution 3.6Å () | |||||||
|---|---|---|---|---|---|---|---|
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
3kg2 is a 4 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.
The homomeric rat GluA2 receptor with the .
Domains
The subunits themselves are modular [1] and in the major domains are found in layers in the tetramer.
- The 'top' layer is composed of the
.
To help give a better idea of how the glutamate receptor is oriented on the cell surface in the membrane lipid bilayer, as calculated by the Orientations of Proteins in Membranes database(University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell.
PDB Entry
3kg2 is a 4 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA. Although it is billed as the first structure of a full-length glutamate receptor, the carboxy-terminal domain is not present in the structure.
Reference for the structure
- Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 2009 Dec 10;462(7274):745-56. Epub . PMID:19946266 doi:10.1038/nature08624
Related Structures
- 3kgc GluA2 ligand-binding core complex bound with glutamate
- 2a5t GluN1-GluN2A ligand-binding domain heterodimer
- 2a5s GluN2A ligand-binding domain bound with glutamate
See Also
Page started with original page seeded by OCA on Wed Dec 16 11:24:54 2009 for 3kg2.
