User:Wayne Decatur/Sandbox Glutamate receptor

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====Transmembrane domain====
====Transmembrane domain====
I NEED TO LABEL THE SEGMENTS BY COLOR- SHOULD I LIST THEM TOO? PROBABLY!!
I NEED TO LABEL THE SEGMENTS BY COLOR- SHOULD I LIST THEM TOO? PROBABLY!!
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<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Transmem/4'>Transmembrane segments M1 to M4 depicted in different colors to show the approximate 4-fold rotation symmetry of the entire domain.</scene>
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<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Transmem/3'>Transmembrane segments M1 to M4 depicted in different colors to show the approximate 4-fold rotation symmetry of the entire domain.</scene>
Segments shown <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Transmem/4'>Parallel to the four-fold axis</scene>
Segments shown <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Transmem/4'>Parallel to the four-fold axis</scene>
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To better show the contributions of each of the membrane segments to the interactions, <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Trans_surf/2'>the transmembrane domains of subunit B to D are shown in a surface representation with the segments M1-M4 of subunit A show as green cylinders</scene>.
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To better show the contributions of each of the membrane segments to the interactions, <scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Trans_surf/3'>the transmembrane domains of subunit B to D are shown in a surface representation with the segments M1-M4 of subunit A show as green cylinders</scene>.

Revision as of 03:58, 4 July 2010


Contents

AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775

Template:ABSTRACT PUBMED 19946266

Background

Citations [1][2] .

About this Structure

PDB ID 3kg2

Drag the structure with the mouse to rotate
glutamate receptor (3kg2), resolution 3.6Å ()
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


The homomeric rat GluA2 receptor that are arranged to form a 'Y'-shape with the [3].

Domains

The subunits themselves are modular [4]and in the major domains are found in layers in the tetrameric structure.

The 'top' layer is composed of the


.


To help give a better idea of how the glutamate receptor is oriented on the cell surface in the membrane lipid bilayer, as calculated by the Orientations of Proteins in Membranes database(University of Michigan, USA) is shown with the red patch of spheres indicating the boundary of the hydrophobic core closet to the outside of the cell and the dark blue patch of spheres indicating the boundary closest to the inside of the cell.

Transmembrane domain

I NEED TO LABEL THE SEGMENTS BY COLOR- SHOULD I LIST THEM TOO? PROBABLY!!

Segments shown

To better show the contributions of each of the membrane segments to the interactions, .


PDB Entry

3kg2 is a 4 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA. Although it is billed as the first structure of a full-length glutamate receptor, the carboxy-terminal domain is not present in the structure.

Reference for the structure

  • Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 2009 Dec 10;462(7274):745-56. Epub . PMID:19946266 doi:10.1038/nature08624

Related Structures

  • 3kgc GluA2 ligand-binding core complex bound with glutamate
  • 2a5t GluN1-GluN2A ligand-binding domain heterodimer
  • 2a5s GluN2A ligand-binding domain bound with glutamate

See Also

References

  1. ↑ Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 2009 Dec 10;462(7274):745-56. Epub . PMID:19946266 doi:10.1038/nature08624
  2. ↑ Wollmuth LP, Traynelis SF. Neuroscience: Excitatory view of a receptor. Nature. 2009 Dec 10;462(7274):729-31. PMID:20010675 doi:10.1038/462729a
  3. ↑ Sobolevsky AI, Rosconi MP, Gouaux E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 2009 Dec 10;462(7274):745-56. Epub . PMID:19946266 doi:10.1038/nature08624
  4. ↑ Wo ZG, Oswald RE. Unraveling the modular design of glutamate-gated ion channels. Trends Neurosci. 1995 Apr;18(4):161-8. PMID:7539962

Page started with original page seeded by OCA on Wed Dec 16 11:24:54 2009 for 3kg2.

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Wayne Decatur

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