Gyrase

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<applet load='3l6v.pdb' size='350' frame='true' align='right' scene="Gyrase/Gyrase_starting_scene/1" caption= 'Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain, [[3l6v]]' />
<applet load='3l6v.pdb' size='350' frame='true' align='right' scene="Gyrase/Gyrase_starting_scene/1" caption= 'Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain, [[3l6v]]' />
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'''3D Structure of Gyrase''' <br />
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'''Gyrase (Gyr)''' is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil.
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The image at the left is a Crystal Structure of the Gyrase A C-terminal Domain([[3l6v]])
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==Gyrase==
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Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil.<br /><br /><br />
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==3D Structure of Gyrase==
==3D Structure of Gyrase==

Revision as of 06:15, 26 July 2010

Image:3L6V.jpg
Crystal Structure of Xanthomonas campestris Gyrase A C-terminal Domain, 3l6v

Crystal Structure of the Xanthomonas campestris Gyrase A C-terminal Domain, 3l6v

Drag the structure with the mouse to rotate

Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA. Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil.

Contents

3D Structure of Gyrase

Gyrase Subunit A

3l6v – GyrA C-terminal – Xanthomonas campestris
2wl2 – EcGyrA N-terminal+simocylinone – Escherichia coli
1ajb - EcGyrA N-terminal+novobiocin
1zi0, 1ab4 - EcGyrA C-terminal
1x75 – EcGyrA14+CcdB
3ilw - MtGyrA N-terminal – Mycobacterium tuberculosis
1suu - GyrA C-terminal – Borrelia burgdorferi

Gyrase Subunit B

3g75, 3g7b, 3g7e – GyrB+thiazole inhibitor – Staphylococcus aureus
2cjt - MtGyrB C-terminal
3cwv – GyrB truncated – Myxococcus xanthus
1kzn, 1ei1 - EcGyrB N-terminal+clorobiocin
1kij – GyrB domain+novobiocin – Thermus thermophilus

Reverse Gyrase

1gku – AfTop-RG – Archaeoglobus fulgidus
1gl9 - AfTop-RG+ADPNP

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman

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