1e5d
From Proteopedia
(New page: 200px<br /> <applet load="1e5d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e5d, resolution 2.50Å" /> '''RUBREDOXIN OXYGEN:O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E5D is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]] with FMN, FEO and OXY as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E5D OCA]]. | + | 1E5D is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]] with FMN, FEO and OXY as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: FEA, FEB, FMA and FMB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E5D OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxygenreductase]] | [[Category: oxygenreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:51:58 2007'' |
Revision as of 08:47, 30 October 2007
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RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS
Overview
Desulfovibrio gigas is a strict anaerobe that contains a, well-characterized metabolic pathway that enables it to survive transient, contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct, and safe way. The 2.5 A resolution crystal structure of ROO shows that, each monomer of this homodimeric enzyme consists of a novel combination of, two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain, that contains a di-iron center for dioxygen reduction. This is the first, structure of a member of a superfamily of enzymes widespread in strict and, facultative anaerobes, indicating its broad physiological significance.
About this Structure
1E5D is a [Single protein] structure of sequence from [Desulfovibrio gigas] with FMN, FEO and OXY as [ligands]. Structure known Active Sites: FEA, FEB, FMA and FMB. Full crystallographic information is available from [OCA].
Reference
Structure of a dioxygen reduction enzyme from Desulfovibrio gigas., Frazao C, Silva G, Gomes CM, Matias P, Coelho R, Sieker L, Macedo S, Liu MY, Oliveira S, Teixeira M, Xavier AV, Rodrigues-Pousada C, Carrondo MA, Le Gall J, Nat Struct Biol. 2000 Nov;7(11):1041-5. PMID:11062560
Page seeded by OCA on Tue Oct 30 10:51:58 2007
Categories: Desulfovibrio gigas | Single protein | Carrondo, M.A. | Coelho, R. | Frazao, C. | Gall, J.Le. | Gomes, C.M. | Liu, M.Y. | Macedo, S. | Matias, P. | Oliveira, S. | Rodrigues-Pousada, C. | Sieker, L. | Silva, G. | Teixeira, M. | Xavier, A.V. | FEO | FMN | OXY | Diiron-centre | Flavoproteins | Lactamase-fold | Oxidoreductase | Oxygenreductase
