1gz5
From Proteopedia
(New page: 200px<br /> <applet load="1gz5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gz5, resolution 2.43Å" /> '''TREHALOSE-6-PHOSPHA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GZ5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with G6P, UDP and IMD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.15 2.4.1.15]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZ5 OCA]]. | + | 1GZ5 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with G6P, UDP and IMD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Alpha,alpha-trehalose-phosphate_synthase_(UDP-forming) Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.15 2.4.1.15]]. Structure known Active Site: UDA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZ5 OCA]]. |
==Reference== | ==Reference== | ||
Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA., Gibson RP, Turkenburg JP, Charnock SJ, Lloyd R, Davies GJ, Chem Biol. 2002 Dec;9(12):1337-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12498887 12498887] | Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA., Gibson RP, Turkenburg JP, Charnock SJ, Lloyd R, Davies GJ, Chem Biol. 2002 Dec;9(12):1337-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12498887 12498887] | ||
| + | [[Category: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: trehalose-6-phosphate]] | [[Category: trehalose-6-phosphate]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:55:58 2007'' |
Revision as of 08:51, 30 October 2007
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TREHALOSE-6-PHOSPHATE SYNTHASE. OTSA
Overview
Trehalose is a nonreducing disaccharide that plays a major role in many, organisms, most notably in survival and stress responses. In Mycobacterium, tuberculosis, it plays a central role as the carbohydrate core of numerous, immunogenic glycolipids including "cord factor" (trehalose, 6,6'-dimycolate). The classical pathway for trehalose synthesis involves, the condensation of UDP-glucose and glucose-6-phosphate to afford, trehalose-6-phosphate, catalyzed by the retaining glycosyltransferase, OtsA. The configurations of two anomeric positions are set simultaneously, resulting in the formation of a double glycoside. The three-dimensional, structure of the Escherichia coli OtsA, in complex with both UDP and, glucose-6-phosphate, reveals the active site at the interface of two, ... [(full description)]
About this Structure
1GZ5 is a [Single protein] structure of sequence from [Escherichia coli] with G6P, UDP and IMD as [ligands]. Active as [Alpha,alpha-trehalose-phosphate synthase (UDP-forming)], with EC number [2.4.1.15]. Structure known Active Site: UDA. Full crystallographic information is available from [OCA].
Reference
Insights into trehalose synthesis provided by the structure of the retaining glucosyltransferase OtsA., Gibson RP, Turkenburg JP, Charnock SJ, Lloyd R, Davies GJ, Chem Biol. 2002 Dec;9(12):1337-46. PMID:12498887
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