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Villin

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[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]
[[Image:2k6n.png|left|thumb|300px|Crystal Strcture of the Human Supervillin Headpiece, [[2k6n]]]]
{{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
{{STRUCTURE_2k6n| right| PDB=2k6n | SCENE=Villin/Cv/1 |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
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[[Villin]] (VIL) is an actin-binding protein. The images at the top and at the right correspond to one representative Villin structure, ''i.e.'' human supervillin headpiece ([[2k6n]]). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. <ref>PMID:10480879</ref> Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the [[Gelsolin]] superfamily which is expressed in the peripheral sensory neurons.
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[[Villin]] (VIL) is an actin-binding protein. The images on the left and right correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. <ref>PMID:10480879</ref> Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.
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== 3D Structures of Villin ==
== 3D Structures of Villin ==
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=== Supervillin ===
=== Supervillin ===

Revision as of 10:34, 2 September 2010

Image:2k6n.png
Crystal Strcture of the Human Supervillin Headpiece, 2k6n

Template:STRUCTURE 2k6n Villin (VIL) is an actin-binding protein. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. [1] Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons.


Contents

3D Structures of Villin






Supervillin

2k6m, 2k6n – hSVIL headpiece– human – NMR

Villin

3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic

Advillin

1und – hAVIL headpiece

References

  1. ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
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