SUMO
From Proteopedia
(New page: Crystal Structure of human SUMO-2 protein, 1wm2 {{STRUCTURE_1wm2| PDB=1wm2 | SIZE=300| SCENE= |right|CAPTION=Human SUMO-2 protein, 1wm2 }}) |
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[[Image:1wm2.png|left|200px|thumb|Crystal Structure of human SUMO-2 protein, [[1wm2]]]] | [[Image:1wm2.png|left|200px|thumb|Crystal Structure of human SUMO-2 protein, [[1wm2]]]] | ||
| - | {{STRUCTURE_1wm2| PDB=1wm2 | SIZE=300| SCENE= |right|CAPTION=Human SUMO-2 protein, [[1wm2]] }} | + | {{STRUCTURE_1wm2| PDB=1wm2 | SIZE=300| SCENE=SUMO/Cv/1 |right|CAPTION=Human SUMO-2 protein, [[1wm2]] }} |
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| + | [[SUMO]] is a small ubiquitin-like modifier which covalently attaches to cellular proteins to modify their function. SUMO is similar in structure but not in sequence to ubiquitin. In several organisms SUMO is called SMT3. The SUMO-conjugating enzyme is called UBC9. The sentrin specific protease (SEPN) cleaves the C-terminal peptide from SUMO which then can bind to E1. The images at the left and at the right correspond to one representative SUMO, ''i.e.'' the crystal structure of human SUMO-2 protein ([[1wm2]]). | ||
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| + | == 3D Structures of SUMO == | ||
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| + | === SUMO === | ||
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| + | [[2k8h]] – SUMO – NMR – ''Trypanosoma brucei''<br /> | ||
| + | [[1u4a]] – hSUMO-3 (mutant) – NMR – human<br /> | ||
| + | [[1wm2]], [[1wm3]] – hSUMO-2<br /> | ||
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| + | === SUMO+ubiquitin-like SUMO-conjugating enzyme === | ||
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| + | [[2vrr]], [[2uyz]] – mSUMO-1+UBC9<br /> | ||
| + | [[2pe6]] - hSUMO-1+UBC9<br /> | ||
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| + | === SUMO+sentrin specific protease === | ||
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| + | [[2io0]] – pre-hSUMO-2+SEPN2<br /> | ||
| + | [[2io1]] - pre-hSUMO-3+SEPN2<br /> | ||
| + | [[2g4d]] - hSUMO-1+SEPN1<br /> | ||
| + | [[2iy1]] - hSUMO-1+SEPN1 (mutant)<br /> | ||
| + | [[2iyd]], [[2ckh]] - hSUMO-2+SEPN1<br /> | ||
| + | [[1tgz]] - hSUMO-1+SEPN2<br /> | ||
| + | [[2io3]] - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)<br /> | ||
| + | [[2iy0]] - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme <br /> | ||
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| + | === SUMO+other proteins === | ||
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| + | [[2asq]] – hSUMO-1+SUMO-binding motif in PIASX<br /> | ||
| + | [[3kyc]], [[3kyd]] – hSUMO+SUMO-activating enzyme <br /> | ||
| + | [[2rpq]] – hSUMO-3+activating transcription factor <br /> | ||
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| + | === SUMO+ubiquitin-conjugating enzyme === | ||
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| + | [[1z5s]] - hSUMO-1+E2+ RAN GTPase-activating enzyme<br /> | ||
| + | [[2bf8]] - SUMO-1+E2 - bovine<br /> | ||
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| + | === SMT3 === | ||
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| + | [[2k1f]] – SMT3 – Fruit fly<br /> | ||
| + | [[2eke]] – ySMT3+UBC9 – yeast<br /> | ||
| + | [[1euv]] – ySMT3+ULP1 protease<br /> | ||
Revision as of 08:54, 26 September 2010
SUMO is a small ubiquitin-like modifier which covalently attaches to cellular proteins to modify their function. SUMO is similar in structure but not in sequence to ubiquitin. In several organisms SUMO is called SMT3. The SUMO-conjugating enzyme is called UBC9. The sentrin specific protease (SEPN) cleaves the C-terminal peptide from SUMO which then can bind to E1. The images at the left and at the right correspond to one representative SUMO, i.e. the crystal structure of human SUMO-2 protein (1wm2).
Contents |
3D Structures of SUMO
SUMO
2k8h – SUMO – NMR – Trypanosoma brucei
1u4a – hSUMO-3 (mutant) – NMR – human
1wm2, 1wm3 – hSUMO-2
SUMO+ubiquitin-like SUMO-conjugating enzyme
2vrr, 2uyz – mSUMO-1+UBC9
2pe6 - hSUMO-1+UBC9
SUMO+sentrin specific protease
2io0 – pre-hSUMO-2+SEPN2
2io1 - pre-hSUMO-3+SEPN2
2g4d - hSUMO-1+SEPN1
2iy1 - hSUMO-1+SEPN1 (mutant)
2iyd, 2ckh - hSUMO-2+SEPN1
1tgz - hSUMO-1+SEPN2
2io3 - pre-hSUMO-2+SEPN2 (mutant)+RAN GTPase-activating enzyme (mutant)
2iy0 - hSUMO-1+SEPN1 (mutant)+RAN GTPase-activating enzyme
SUMO+other proteins
2asq – hSUMO-1+SUMO-binding motif in PIASX
3kyc, 3kyd – hSUMO+SUMO-activating enzyme
2rpq – hSUMO-3+activating transcription factor
SUMO+ubiquitin-conjugating enzyme
1z5s - hSUMO-1+E2+ RAN GTPase-activating enzyme
2bf8 - SUMO-1+E2 - bovine
SMT3
2k1f – SMT3 – Fruit fly
2eke – ySMT3+UBC9 – yeast
1euv – ySMT3+ULP1 protease
