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| - | [[Image:1bov.gif|left|200px]]<br /><applet load="1bov" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[2xsc]] This PDB entry is obsolete and replaced by 2xsc |
| - | caption="1bov, resolution 2.2Å" />
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| - | '''CRYSTAL STRUCTURE OF THE CELL-BINDING B OLIGOMER OF VEROTOXIN-1 FROM E. COLI'''<br />
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| - | ==Overview==
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| - | The Shiga toxin family, a group of cytotoxins associated with diarrhoeal diseases and the haemolytic uraemic syndrome, includes Shiga toxin from Shigella dysenteriae type 1 and verotoxins produced by enteropathogenic Escherichia coli. The family belongs to the A-B class of bacterial toxins, which includes the cholera toxin family, pertussis and diphtheria toxins. These toxins all have bipartite structures consisting of an enzymatic A subunit associated with a B oligomer which binds to specific cell-surface receptors, but their amino-acid sequences and pathogenic mechanisms differ. We have determined the crystal structure of the B oligomer of verotoxin-1 from E. coli. The structure unexpectedly resembles that of the B oligomer of the cholera toxin-like heat-labile enterotoxin from E. coli, despite the absence of detectable sequence similarity between these two proteins. This result implies a distant evolutionary relationship between the Shiga toxin and cholera toxin families. We suggest that the cell surface receptor-binding site lies in a cleft between adjacent subunits of the B pentamer, providing a potential target for drugs and vaccines to prevent toxin binding and effect.
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| - | ==About this Structure==
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| - | 1BOV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOV OCA].
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| - | ==Reference==
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| - | Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli., Stein PE, Boodhoo A, Tyrrell GJ, Brunton JL, Read RJ, Nature. 1992 Feb 20;355(6362):748-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1741063 1741063]
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| - | [[Category: Escherichia coli]]
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| - | [[Category: Single protein]]
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| - | [[Category: Read, R J.]]
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| - | [[Category: Stein, P E.]]
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| - | [[Category: ZN]]
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| - | [[Category: toxin]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:57:30 2008''
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Current revision
- REDIRECT 2xsc This PDB entry is obsolete and replaced by 2xsc
