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| - | [[Image:1bov.gif|left|200px]] | + | #REDIRECT [[2xsc]] This PDB entry is obsolete and replaced by 2xsc |
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| - | {{Structure
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| - | |PDB= 1bov |SIZE=350|CAPTION= <scene name='initialview01'>1bov</scene>, resolution 2.2Å
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| - | |SITE=
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| - | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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| - | |ACTIVITY=
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| - | |GENE=
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| - | |DOMAIN=
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| - | |RELATEDENTRY=
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| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bov OCA], [http://www.ebi.ac.uk/pdbsum/1bov PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bov RCSB]</span>
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| - | }}
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| - | '''CRYSTAL STRUCTURE OF THE CELL-BINDING B OLIGOMER OF VEROTOXIN-1 FROM E. COLI'''
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| - | ==Overview==
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| - | The Shiga toxin family, a group of cytotoxins associated with diarrhoeal diseases and the haemolytic uraemic syndrome, includes Shiga toxin from Shigella dysenteriae type 1 and verotoxins produced by enteropathogenic Escherichia coli. The family belongs to the A-B class of bacterial toxins, which includes the cholera toxin family, pertussis and diphtheria toxins. These toxins all have bipartite structures consisting of an enzymatic A subunit associated with a B oligomer which binds to specific cell-surface receptors, but their amino-acid sequences and pathogenic mechanisms differ. We have determined the crystal structure of the B oligomer of verotoxin-1 from E. coli. The structure unexpectedly resembles that of the B oligomer of the cholera toxin-like heat-labile enterotoxin from E. coli, despite the absence of detectable sequence similarity between these two proteins. This result implies a distant evolutionary relationship between the Shiga toxin and cholera toxin families. We suggest that the cell surface receptor-binding site lies in a cleft between adjacent subunits of the B pentamer, providing a potential target for drugs and vaccines to prevent toxin binding and effect.
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| - | ==About this Structure==
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| - | 1BOV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOV OCA].
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| - | ==Reference==
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| - | Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli., Stein PE, Boodhoo A, Tyrrell GJ, Brunton JL, Read RJ, Nature. 1992 Feb 20;355(6362):748-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1741063 1741063]
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| - | [[Category: Escherichia coli]]
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| - | [[Category: Single protein]]
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| - | [[Category: Read, R J.]]
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| - | [[Category: Stein, P E.]]
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| - | [[Category: toxin]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:05:17 2008''
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