Sandbox c2
From Proteopedia
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| - | Los receptores de hormonas tiroideas: | ||
| - | <Structure load='1NAX' size='300' frame='true' align='right' caption=' | + | |
| + | <Structure load='1NAX' size='300' frame='true' align='right' caption='1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | ||
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| + | Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | ||
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| + | It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
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| + | Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330). | ||
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| + | Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649' /> | ||
Revision as of 12:17, 23 November 2010
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